AI Article Synopsis
- The study investigates the protective effects of alcoholic extracts from specific leaves against liver and kidney toxicity caused by thioacetamide (TAA) in adult Wistar rats.
- Rats were treated with these extracts for 14 days, then injected with TAA, after which various biochemical markers and liver functions were assessed.
- Results indicated that the leaf extracts significantly reduced the toxic effects of TAA, improving liver and kidney function through their antioxidant and anti-inflammatory properties.
Article Abstract
The present work has been designed to investigate the hepatoprotective and renoprotective efficiency of alcoholic extract of and leaves in thioacetamide-induced toxicity in adult Wistar rats. leaf extract, leaf extract and their combinations were orally administered for 14 days then TAA (300 mg/kg) i.p. was injected once and the rats were sacrificed 2 days later. Plasma AST, ALT, GGT, total bilirubin, creatinine, urea, uric acid, triglyceride, cholesterol, HDL and LDL were measured. Liver MDA, GSH, CAT, SOD and TNF-α were evaluated. Histological examination was performed. The rats treated with TAA showed a significant increase in AST, ALT, GGT, total bilirubin, creatinine, urea, uric acid, total, triglyceride, cholesterol and HDL while it led to a significant decrease in protein and HDL. The treatment of rats with TAA resulted in a significant decrease of the hepatic GSH, SOD and CAT and a significant elevation of MDA and TNF-α. and extracts alleviated the toxic effects of TAA on the liver and the kidney. In conclusion, treatment with and extracts and their combination reduced deleterious effects of TAA on liver through antioxidant and anti-inflammatory properties.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093619 | PMC |
| http://dx.doi.org/10.1007/s12291-018-0803-5 | DOI Listing |
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