A high-sensitivity photoacoustic (PA) spectroscopy (PAS) system is proposed for dual enhancement from both PA signal excitation and detection by employing a miniaturized Herriott cell and a fiber-optic microphone (FOM). The length of the optical absorption path of the PA cell is optimized to ∼374 mm with 17 reflections. The volume of the PA cell is only 622 µL. The FOM is a low-finesse fiber-optic Fabry-Pérot (FP) interferometer. The two reflectors of the FP cavity are formed by a fiber endface and a circular titanium diaphragm with a radius of 4.5 mm and a thickness of 3 µm. A fast demodulated white-light interferometer (WLI) is utilized to measure the absolute FP cavity length. The acoustic responsivity of the FOM reaches 126.6 nm/Pa. Several representative PA signals of trace acetylene (CH) are detected to evaluate the performance of the trace gas detector in the near-infrared region. Experimental results show that the minimum detectable pressure (MDP) of the FOM is 3.8 µPa/Hz at 110 Hz. The noise equivalent minimum detection concentration is measured to be 8.4 ppb with an integration time of 100 s. The normalized noise equivalent absorption (NNEA) coefficient is calculated as 1.4×10 cm·W·Hz.
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Micromachines (Basel)
November 2024
Beijing Key Laboratory for Precision Optoelectronic Measurement Instrument and Technology, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, China.
Photoacoustic imaging has emerged as a promising modality for medical imaging since its introduction. Photoacoustic microscopy (PAM), which is based on the photoacoustic effect, combines the advantages of both optical and acoustic imaging modalities. PAM facilitates high-sensitivity, high-resolution, non-contact, and non-invasive imaging by employing optical absorption as its primary contrast mechanism.
View Article and Find Full Text PDFAnal Chem
January 2025
State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Gansu, Lanzhou 730000, China.
Adv Mater
January 2025
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China.
Breast cancer (BC) is the second most common cause of cancer induced death worldwide. Current statistics has disclosed that the diabetic BC patients have significantly worse survival rate compared with nondiabetic BC patients. However, the specific mechanism is still being explored.
View Article and Find Full Text PDFPhotoacoustics
February 2025
Dipartimento di Scienze di Base ed Applicate per l'Ingegneria, Sapienza Università di Roma, Rome 00161, Italy.
A compact and robust optical excitation photoacoustic sensor with a self-integrated laser module excitation and an optimized differential resonator was developed to achieve high sensitivity and full linear range detection of carbon dioxide (CO) based on dual modes of wavelength modulated photoacoustic spectroscopy (WMPAS) and resonant frequency tracking (RFT). The integrated laser module equipped with three lasers (a quantum cascade laser (QCL), a distributed feedback laser (DFB) and a He-Ne laser) working in a time-division multiplexing mode was used as an integrated set of spectroscopic sources for detection of the designated concentration levels of CO. With the absorption photoacoustic mode, the WMPAS detection with the QCL and DFB sources was capable of CO detection at concentrations below 20 %, yielding a noise equivalent concentration (NEC) as low as 240 ppt and a normalized noise equivalent absorption coefficient (NNEA) of 4.
View Article and Find Full Text PDFTalanta
December 2024
Department of Hepato-Pancreato-Biliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315211, China; Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China. Electronic address:
The hypoxic environment in tumors is closely linked to tumor structure, function, dissemination, invasion, metastasis, and drug resistance. Nitroreductase (NTR) is often recognized as a biomarker to evaluate the hypoxia degree for tumor cells. Traditional detection methods such as PET, MRI and multispectral photoacoustic tomography have limitations.
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