Adaptive optics are crucial for overcoming the fabrication limits on mirror curvature in high-precision interferometry. We describe a low-cost thermally actuated bimorph mirror with 200 mD linear response, which meets dynamic range and low aberration requirements for the ${\rm{A}} + $A+ upgrade of the Laser Interferometer Gravitational-wave Observatory (LIGO). Its deformation and operation limits were measured and verified against finite element simulation.
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http://dx.doi.org/10.1364/AO.376764 | DOI Listing |
BMC Microbiol
December 2024
Department of Physics, College of Science, University of Halabja, Halabja, Kurdistan Region, Iraq.
Background: Antimicrobial resistance (AMR) presents a serious threat to health, highlighting the urgent need for more effective antimicrobial agents with innovative mechanisms of action. Nanotechnology offers promising solutions by enabling the creation of nanoparticles (NPs) with antibacterial properties. This study aimed to explore the antibacterial, anti-biofilm, and anti-virulence effects of eco-friendly synthesized α-Fe₂O₃ nanoparticles (α-Fe₂O₃-NPs) against pathogenic bacteria.
View Article and Find Full Text PDFAm J Physiol Gastrointest Liver Physiol
December 2024
Health and Biosecurity, CSIRO,, Sydney, New South Wales Australia.
The intestinal microenvironment represents a complex and dynamic ecosystem, comprising a diverse range of epithelial and non-epithelial cells, a protective mucus layer, and a diverse community of gut microbiota. Understanding the intricate interplay between these components is essential for uncovering the mechanisms underlying intestinal health and disease. The development of intestinal organoids, 3D mini-intestines that closely mimic the architecture, cellular diversity, and functionality of the intestine, offers a powerful platform for investigating different aspects of intestinal physiology and pathology.
View Article and Find Full Text PDFMethods Mol Biol
December 2024
Department of Environmental Toxicology, The University of California, Davis, Davis, CA, USA.
Biological fluids are proteinaceous liquids or suspensions released through different body orifices or through penetration of the skin. These fluids are the result of multiple tissues and cell types and contain extensive, highly complex, and dynamic protein populations that reflect both the transcriptional program of the originating cells and a record of the individual's health status. Body fluids are readily accessible to clinicians and researchers, and as such proteomic analyses are an important component of clinical studies, fertility studies, oral health studies, and forensic investigations.
View Article and Find Full Text PDFMethods Mol Biol
December 2024
Department of Biological Sciences, University of the Pacific, Stockton, CA, USA.
Adipose tissue (AT) is a complex, multifunctional endocrine organ that plays a significant role in animal evolution and human disease. Profiling of the proteome, or the set of proteins produced by a cell or tissue at a given time, can be used to explore the myriad functions of adipose tissue and understand its role in health and disease. The main challenges of adipose tissue proteomics include the high lipid and low protein content of the tissue and association of many proteins with lipid droplets.
View Article and Find Full Text PDFMethods Mol Biol
December 2024
UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Mass spectrometry-based proteomics is widely applied to human blood serum or plasma in the search of biomarkers for various diseases. However, the enormous complexity and dynamic range of protein concentrations in these samples render a significant analytical challenge, particularly for detecting low-abundance candidate biomarkers. As a result, strategies for enriching low-abundance proteins and improving their identification in serum or plasma proteomics are commonly used.
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