This work investigates the excitation of dense comb-like enhanced leaky mode resonance (eLMR) in tilted fiber Bragg grating (TFBG) integrated with indium tin oxide (ITO) nanocoating. The ITO overlay leads to a large reduction in mode loss and a great increase of propagation length for s-polarized leaky modes, which means the leaky modes become guided. The guidance of leaky modes enhances significantly the interaction with the core guided mode, which leads to the generation of strong dense comb-like eLMR. The results show that the ultra-narrow eLMR bands present promising sensing performance with an extended measurement range and provide advantages of high Q measurement over the case of surface plasmon resonance (SPR) and lossy mode resonance (LMR). The similarities and differences between the eLMR and SPR and LMR are also discussed. This study offers new opportunities to develop eLMR-based multifunctional fiber-optic devices with high performance.
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http://dx.doi.org/10.1364/OE.389363 | DOI Listing |
Acta Biomater
January 2025
College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China. Electronic address:
Cuproptosis is a newly discovered mode of cell death, which is caused by excess copper and results in cell death via the mitochondrial pathway. However, the complex tumor microenvironment (TME) is characterized by many factors, including high levels of glutathione and lack O, limit the application of traditional cuproptosis agents in antitumor therapy. Herein, we report a hyaluronic acid modified copper-manganese composite nanomedicine (CMCNs@HA) to remodel the TME and facilitate efficient cuproptosis in tumor.
View Article and Find Full Text PDFBrain Struct Funct
January 2025
Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
A significant proportion of patients who have recovered from COVID-19 suffer from persistent symptoms, referred to as "post-acute sequelae of SARS-CoV-2 infection (PASC)". Abnormal brain intrinsic activity has been observed in PASC patients, but the patterns of frequency-dependent intrinsic activity in the PASC and non-PASC (recovered COVID-19 patients without persistent symptoms) groups and their association with neuropsychiatric sequelae remain unclear in PASC. Twenty-nine PASC patients, 27 non-PASC subjects, and 31 healthy controls (HCs) were recruited.
View Article and Find Full Text PDFNano Lett
January 2025
Max Planck Institute for Chemical Physics of Solids, 01187 Dresden, Germany.
The advent of two-dimensional van der Waals materials is a frontier of condensed matter physics and quantum devices. However, characterizing such materials remains challenging due to the limitations of bulk material techniques, necessitating the development of specialized methods. Here, we investigate the superconducting properties of BiSrCaCuO flakes by integrating them with a hybrid superconducting microwave resonator.
View Article and Find Full Text PDFJ Gerontol B Psychol Sci Soc Sci
January 2025
Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Objectives: Subthreshold depression (SD) is common in the older population, more so in females than males, and can lead to serious physical and mental ill-health. However, the underlying neurobiology remains unclear. This study used multimodal magnetic resonance imaging (MRI) to investigate the topological organization and coupling of the structural and functional brain networks in older women with SD.
View Article and Find Full Text PDFNeuroimage Clin
January 2025
Backgrounds/objective: Deep brain stimulation (DBS) has proved the viability of alleviating depression symptoms by stimulating deep reward-related nuclei. This study aims to investigate the abnormal connectivity profiles among superficial, intermediate, and deep brain regions within the reward circuit in major depressive disorder (MDD) and therefore provides references for identifying potential superficial cortical targets for non-invasive neuromodulation.
Methods: Resting-state functional magnetic resonance imaging data were collected from a cohort of depression patients (N = 52) and demographically matched healthy controls (N = 60).
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