A nitridated / multilayer with period of 3.0 nm and 80 bilayers were fabricated to study thermal and temporal stability. The multilayer was annealed from room temperature to 490°C, and the in situ X-ray measurements showed that the reflectivity remains mostly unchanged up to 300°C. An essential drop of the reflectivity occurred at 490°C with significantly increased interface roughness. A new layered structure with larger thickness than the original multilayer started to appear at 400°C. The nitridated / multilayer remains intact after two years of storage in air, which demonstrated a very good temporal stability.
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http://dx.doi.org/10.1364/AO.59.000A48 | DOI Listing |
The concentrations of extracellular and intracellular signaling molecules, such as dopamine and cAMP, change over both fast and slow timescales and impact downstream pathways in a cell-type specific manner. Fluorescence sensors currently used to monitor such signals are typically optimized to detect fast, relative changes in concentration of the target molecule. They are less well suited to detect slowly-changing signals and rarely provide absolute measurements of either fast and slow signaling components.
View Article and Find Full Text PDFEBioMedicine
January 2025
Department of Chemistry, University of Washington, Seattle, WA, USA; Department of Urology, University of Washington, Seattle, WA, USA. Electronic address:
Background: Early host immunity to acute respiratory infections (ARIs) is heterogenous, dynamic, and critical to an individual's infection outcome. Due to limitations in sampling frequency/timepoints, kinetics of early immune dynamics in natural human infections remain poorly understood. In this nationwide prospective cohort study, we leveraged a Tasso-SST based self-blood collection and stabilization tool (homeRNA) to profile detailed kinetics of the presymptomatic to convalescence host immunity to contemporaneous respiratory pathogens.
View Article and Find Full Text PDFChild Abuse Negl
January 2025
Department of Sociology, University of Oklahoma, Norman, OK 73019-2033, USA. Electronic address:
Background: Neighborhoods and families are crucial contexts for child maltreatment, yet research into mechanisms of neighborhood effects on child maltreatment remains limited.
Objective: This study examined longitudinal associations between neighborhood collective efficacy, maternal parenting stress, and child maltreatment.
Participants And Setting: The study drew data from the Future of Families and Child Wellbeing Study (FFCWS).
Semergen
January 2025
Departamento de Psicología de la Salud, Universidad Miguel Hernández, Elche, Alicante, España.
Aim: The use of oral anticoagulants has increased due to the rising prevalence of auricular fibrillation, a condition that raises the risk of thromboembolic events. These drugs are effective in preventing such events, but their success depends on therapeutic adherence, which requires validated tools for assessment. The aim of this study is to evaluate the suitability of the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire in its adapted version for the Spanish population.
View Article and Find Full Text PDFJ Neurol
January 2025
Centre de Génétique Humaine, Centre Hospitalier Universitaire de Besançon, Besançon, France.
Introduction: The MAPT gene encodes Tau, a protein mainly expressed by neurons. Tau protein plays an important role in cerebral microtubule polymerization and stabilization, in axonal transport and synaptic plasticity. Heterozygous pathogenic variation in MAPT are involved in a spectrum of autosomal dominant neurodegenerative diseases known as taupathies, including Alzheimer's disease, Pick's disease, fronto-temporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
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