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| http://dx.doi.org/10.3960/jslrt.19044 | DOI Listing |
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The impact of X-rays on cardiac hydrometabolism and the regulatory role of AS-IV.
Int Immunopharmacol
December 2024
Gansu University of Chinese Medicine, LanZhou, China; Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China; Key Laboratory of Dunhuang Medicine and Transformation at Provincial and Ministerial Level, Lanzhou, China. Electronic address:
Background: Radiation-induced cardiac injury has emerged as a significant pathological entity, with many studies focusing on the fibrotic changes in myocardial tissue. However, these do not offer solutions for the clinical prevention and treatment of radiation-induced heart disease. Regulating hydrometabolism presents a potential therapeutic target for the management of cardiovascular diseases.
View Article and Find Full Text PDFTissue microarray analyses of the essential DNA repair factors ATM, DNA-PKcs and Ku80 in head and neck squamous cell carcinoma.
Radiat Oncol
October 2024
Department of Otorhinolaryngology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: Head and neck squamous cell carcinoma (HNSCC) negative for Human Papillomavirus (HPV) has remained a difficult to treat entity, whereas tumors positive for HPV are characterized by radiosensitivity and favorable patient outcome. On the cellular level, radiosensitivity is largely governed by the tumor cells` ability to repair radiation-induced DNA double-strand breaks (DSBs), but no biomarker is established that could guide clinical decision making. Therefore, we tested the impact of the expression levels of ATM, the central kinase of the DNA damage response as well as DNA-PKcs and Ku80, two major factors in the main DSB repair pathway non-homologous end joining (NHEJ).
View Article and Find Full Text PDFTargeting Oxidative Stress: The Potential of Vitamin C in Protecting against Liver Damage after Electron Beam Therapy.
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Department of Digital Oncomorphology, National Medical Research Centre of Radiology, 2nd Botkinsky Pass., 3, 125284 Moscow, Russia.
Article Synopsis
- - Radiation-induced liver disease (RILD) is a serious side effect of radiotherapy used for abdominal cancers, particularly affecting the liver's crucial functions and limiting the overall effectiveness of treatment.
- - Electron beam therapy has shown promise in targeting tumors with less damage to surrounding healthy tissue, but the long-term effects on liver health and the potential for chronic damage need further research, especially regarding vitamin C's protective qualities.
- - A study involving male Wistar rats examined the impact of electron beam radiation and vitamin C on liver health, showing that radiation caused weight loss and liver mass reduction, while various biochemical and genetic analyses provided insights into how vitamin C might mitigate some of these adverse effects.
DOSIMETRIC AND EARLY CLINICAL OUTCOMES OF THYROID-SPARING VOLUMETRIC MODULATED ARC RADIOTHERAPY IN LOCALLY ADVANCED HEAD AND NECK CANCERS.
Acta Endocrinol (Buchar)
October 2024
Department of Radiotherapy and Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Introduction: Radiation-induced hypothyroidism is a well-recognized entity that occurs after an interval of 15-21 months. However, in the treatment of locally advanced Head and neck Squamous cell carcinoma (HNSCC), thyroid-sparing techniques are infrequently employed.
Aims: To evaluate the dosimetric and early clinical outcomes of thyroid-sparing SIB-VMAT technique (Simultaneous Integrated Boost - Volumetric Modulated Arc Radiotherapy) in patients of locally advanced HNSCC.
Assessment of secondary cancer risks within non-target organs during proton therapy for lung cancer: A Monte Carlo study.
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December 2024
Physics Department, Hakim Sabzevari University, Sabzevar, Iran.
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- Proton therapy is advancing as a treatment for lung cancer, but there are concerns about the potential for secondary radiation effects on non-target organs.
- This study utilized a Monte Carlo model to assess the radiation dose to out-of-field organs and estimated the risk of secondary cancers using established risk models.
- Results showed that organs near the tumor, particularly the liver and esophagus, received significant doses, and the risk of secondary cancers increased with tumor depth, highlighting the need for careful management during treatment.
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