AI Article Synopsis
- Fanconi anemia is a group of disorders linked to genomic instability, and a study examined HLA allele frequencies in 40 Iranian patients compared to 40 healthy individuals.
- The study found a significant increase in the presence of the HLA-DRB1*11 allele among patients, while alleles DRB1*13 and B*13 were less frequent in patients than in controls.
- Results indicate a clear genetic divergence in HLA alleles between those with Fanconi anemia and healthy individuals, suggesting different immune profile distributions.
Article Abstract
Fanconi anemia includes a number of clinically and genetically diverse disorders all of them being associated with genomic instability. Some previous studies reported higher frequencies of certain HLA alleles in patients with Fanconi anemia. In the current study, we genotyped HLA-A/B/DRB1 alleles in 40 Iranian patients with Fanconi anemia. We also genotyped these alleles in the same number of Iranian sex-matched healthy individuals. The frequency of DRB1*11 was significantly higher in patients compared with controls (OR (95% CI) = 2.143 [1.05, 4.46], P value = 0.036). On the other hand, the frequencies of DRB1*13 and B*13 were lower in patients compared with controls (OR (95% CI) = 0.134 [0.02, 0.55], P value = 0.003 and OR (95% CI) = 0.13 [0.01, 0.89], P value = 0.035, respectively). Assessment of genetic divergence using Fstat test showed complete divergence in HLA-A, -B, -DRB1 alleles and haplotypes between patients and controls. The current study provides evidences for different distribution of HLA alleles between patients with Fanconi anemia and healthy subjects.
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| http://dx.doi.org/10.3233/HAB-200410 | DOI Listing |
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