AI Article Synopsis
- TLR2 is a key player in the body's inflammatory response to bacterial infections, and previous studies on its Arg677Trp genetic variant's link to tuberculosis (TB) have produced mixed results.
- This study aimed to clarify the relationship between the TLR2 Arg677Trp polymorphism and susceptibility to TB through a meta-analysis of existing data.
- The findings showed no significant association between the TLR2 Arg677Trp variant and TB risk, indicating that this genetic polymorphism does not influence susceptibility to the disease.
Article Abstract
Background: Toll-like receptor 2 (TLR2) is an important member of TLRs, which is significant in the initial of inflammatory response against bacteria. Several studies have been conducted to investigate the TLR2 Arg677Trp polymorphism and Tuberculosis (TB) susceptibility. Unfortunately, the results of previous studies were inconsistent.
Objectives: The aim of present study was to investigate the relationship between TLR2 Arg677Trp polymorphisms and TB susceptibility.
Methods: The association between the TLR2 Arg677Trp polymorphism and TB susceptibility was assessed by odds ratios (OR) together with their 95% confidence intervals (95%CI).
Results: Six case-control studies were enrolled in the meta-analysis. Overall, significant association between TLR2 Arg677Trp polymorphism and TB risk were found neither under allele contrast (C vs. T: OR = 0.59, 95%CI = 0.28-1.23, P = 0.158) nor under recessive genetic model (CC vs. CT/TT: OR = 0.43, 95%CI = 0.12-1.51, P = 0.188).
Conclusion: We conclude that TLR2 Arg677Trp polymorphism is not associated with TB susceptibility.
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| http://dx.doi.org/10.1016/j.micpath.2020.104173 | DOI Listing |
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