Detection of coinfection with Chikungunya virus and Dengue virus serotype 2 in serum samples of patients in State of Tocantins, Brazil.

J Infect Public Health

Laboratório de Retrovirologia, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil; Faculdade de Medicina do ABC, Santo André, SP 09060-870, Brazil. Electronic address:

Published: May 2020

AI Article Synopsis

  • The study investigated cases of coinfection with Chikungunya, Dengue, and Zika viruses in Tocantins, Brazil.
  • In 2017, 102 patient samples showing symptoms of arboviral infections were analyzed, confirming various infections using RT-qPCR.
  • Results showed 52 cases of Chikungunya only, multiple Dengue serotypes, and five instances of coinfection with Chikungunya and Dengue serotype 2, highlighting the need for better diagnosis and vector management.

Article Abstract

Background: The co-circulation of Chikungunya (CHIKV), Dengue (DENV) and Zika (ZIKV) viruses increased the risk of outbreaks and coinfections among them. Here, we report cases of coinfection in clinical samples from state of Tocantins, Brazil.

Methods: In 2017, the Central Public Health Laboratory (LACEN) received samples of patients who consulted health units with symptoms compatible with arboviral infections. A total of 102 samples were sent to the Retrovirology Laboratory at the Federal University of São Paulo, where they were tested by RT-qPCR to confirm DENV, ZIKV and CHIKV infections and to detect coinfected patients.

Results: We identified with CHIKV monoinfection (52), DENV serotypes 1 (28) and serotypes 2 (22). We did not detect ZIKV. Five patients were characterized with coinfection involving CHIKV and DENV serotype 2.

Conclusions: The presence of co-circulating arboviruses increases the chance of coinfection and demonstrates the importance of differential diagnosis and vector control.

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Source
http://dx.doi.org/10.1016/j.jiph.2020.02.034DOI Listing

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