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| http://dx.doi.org/10.1080/01652176.2020.1750114 | DOI Listing |
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Background: Antibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high cytotoxicity. However, complexity of its structural composition poses a greater difficulty for drug design studies.
Objectives: Pharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.
Double bowtie design for high sensitivity pediatric spectral CT.
Conf Proc Int Conf Image Form Xray Comput Tomogr
August 2024
Department of Radiology, Perelman School of Medicine, Philadelphia, PA USA.
Despite the evident benefits of spectral computed tomography (CT) in delivering qualitative imaging superior to that of conventional CT in adults, its application in pediatric diagnostic imaging is still relatively limited due to various reasons, including design limitations and radiation dose considerations. The use of specialized K-edge filters, in conjunction with other spectral technologies, has been demonstrated to improve spectral quantification accuracy. X-ray flux limitations generally pose challenges in these concepts when applied to adults.
View Article and Find Full Text PDFDetection of reproducible liver cancer specific ligand-receptor signaling in blood.
Front Bioinform
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RNA Bioinformatics and High Throughput Analysis, Friedrich Schiller University Jena, Jena, Germany.
Cell-cell communication mediated by ligand-receptor interactions (LRI) is critical to coordinating diverse biological processes in homeostasis and disease. Lately, our understanding of these processes has greatly expanded through the inference of cellular communication, utilizing RNA extracted from bulk tissue or individual cells. Considering the challenge of obtaining tissue biopsies for these approaches, we considered the potential of studying cell-free RNA obtained from blood.
View Article and Find Full Text PDFRepurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and progenitor cells for transplantation.
Front Pharmacol
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Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Objective: The expanding field of hematopoietic cell transplantation (HCT) for non-malignant diseases, including those amenable to gene therapy or gene editing, faces challenges due to limited donor availability and the toxicity associated with cell collection methods. Umbilical cord blood (CB) represents a readily accessible source of hematopoietic stem and progenitor cells (HSPCs); however, the cell dose obtainable from a single cord blood unit is frequently insufficient. This limitation can be addressed by enhancing the potency of HSPCs, specifically their capacity to reconstitute hematopoiesis.
View Article and Find Full Text PDFAgricultural Landscape Genomics to Increase Crop Resilience.
Plant Commun
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Department of Tropical Plant & Soil Sciences, University of Hawaii at Manoa, Honolulu, HI, USA.
Populations are continually adapting to their environment. Knowledge of which populations and individuals harbor unique and agriculturally useful variation has the potential to accelerate crop adaptation to the increasingly challenging environments predicted for the coming century. Landscape genomics, which identifies associations between environmental and genomic variation, provides a means for obtaining this knowledge.
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