AI Article Synopsis
- This study investigates the relationship between various PFAS chemicals and thyroid hormone levels in pregnant women and their newborns, using data from a large cohort enrolled from 2003 to 2006 in Cincinnati, Ohio.
- The researchers employed advanced statistical techniques to analyze the impacts of individual PFAS substances, their interactions, and their overall effects, considering additional factors like thyroid autoantibodies and iodine levels.
- Results showed that, generally, PFAS were not significantly associated with thyroid hormones, though specific associations emerged in children of mothers with higher thyroid autoantibodies, suggesting potential modifications of PFAS effects by maternal health conditions.
Article Abstract
Background: Per- and polyfluoroalkyl substances (PFAS) are ubiquitous. Previous studies have found associations between PFAS and thyroid hormones in maternal and cord sera, but the results are inconsistent. To further address this research question, we used mixture modeling to assess the associations with individual PFAS, interactions among PFAS chemicals, and the overall mixture.
Methods: We collected data through the Health Outcomes and Measures of the Environment (HOME) Study, a prospective cohort study that between 2003 and 2006 enrolled 468 pregnant women and their children in the greater Cincinnati, Ohio region. We assessed the associations of maternal serum PFAS concentrations measured during pregnancy with maternal (n = 185) and cord (n = 256) sera thyroid stimulating hormone (TSH), total thyroxine (TT), total triiodothyronine (TT), free thyroxine (FT), and free triiodothyronine (FT) using two mixture modeling approaches (Bayesian kernel machine regression (BKMR) and quantile g-computation) and multivariable linear regression. Additional models considered thyroid autoantibodies, other non-PFAS chemicals, and iodine deficiency as potential confounders or effect measure modifiers.
Results: PFAS, considered individually or as mixtures, were generally not associated with any thyroid hormones. A doubling of perfluorooctanesulfonic acid (PFOS) had a positive association with cord serum TSH in BKMR models but the 95% Credible Interval included the null (β = 0.09; 95% CrI: -0.08, 0.27). Using BKMR and multivariable models, we found that among children born to mothers with higher thyroid peroxidase antibody (TPOAb), perfluorooctanoic acid (PFOA), PFOS, and perfluorohexanesulfonic acid (PFHxS) were associated with decreased cord FT suggesting modification by maternal TPOAb status.
Conclusions: These findings suggest that maternal serum PFAS concentrations measured in the second trimester of pregnancy are not strongly associated with thyroid hormones in maternal and cord sera. Further analyses using robust mixture models in other cohorts are required to corroborate these findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657649 | PMC |
| http://dx.doi.org/10.1016/j.envres.2020.109395 | DOI Listing |
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