Objective: To investigate how high frequency oscillations (HFOs; ripples 80-250 Hz, fast ripples (FRs) 250-500 Hz) and spikes in intra-operative electrocorticography (ioECoG) relate to cognitive outcome after epilepsy surgery in children.
Methods: We retrospectively included 20 children who were seizure free after epilepsy surgery using ioECoG and determined their intelligence quotients (IQ) pre- and two years postoperatively. We analyzed whether the number of HFOs and spikes in pre- and postresection ioECoGs, and their change in the non-resected areas relate to cognitive improvement (with ≥ 5 IQ points increase considered to be clinically relevant (=IQ+ group) and < 5 IQ points as irrelevant (=IQ- group)).
Results: The IQ+ group showed significantly more FRs in the resected tissue (p = 0.01) and less FRs in the postresection ioECoG (p = 0.045) compared to the IQ- group. Postresection decrease of ripples on spikes was correlated with postoperative cognitive improvement (correlation coefficient = -0.62 with p = 0.01).
Conclusions: Postoperative cognitive improvement was related to reduction of pathological HFOs signified by removing FR generating areas with subsequently less residual FRs, and decrease of ripples on spikes in the resection edge of the non-resected area.
Significance: HFOs recorded in ioECoG could play a role as biomarkers in the prediction and understanding of cognitive outcome after epilepsy surgery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clinph.2020.01.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Connections among family socioeconomic status, aerobic fitness, executive function, and the positive experiences of childhood physical activity.
J Exp Child Psychol
December 2024
Department of Human Services, Western Carolina University, Cullowhee, NC 28723, USA.
A family's socioeconomic status (SES) can be linked to a child's physical and cognitive health, with children from low-SES families often experiencing poor developmental outcomes. Early positive childhood experiences that include structured and unstructured physical activities (SUPAs) offer a potential avenue to promote positive health and cognitive development during early childhood. However, prior to school entry, it is not well-understood whether SES is related to participation in SUPAs or how SUPAs relate to early health and cognitive indicators such as aerobic fitnessand executive function (EF).
View Article and Find Full Text PDFFactors associated with patients' demand for low-value care: a scoping review.
BMC Health Serv Res
December 2024
Department of Health Economics and Health Services Research, National Institute for Public Health and the Environment (RIVM), P.O. Box 13720, Antonie van Leewenhoeklaan 9, Bilthoven, BA, Netherlands.
Background: Low-value care is unnecessary care that contributes to inefficient use of health resources and constitutes a considerable proportion of healthcare expenditures worldwide. Factors contributing to patients' demand for low-value care have often been overlooked and are dispersed in the literature. Therefore, the current study aimed to systematically summarize factors associated with patients' demand for low-value care.
View Article and Find Full Text PDFSensory representations and pupil-indexed listening effort provide complementary contributions to multi-talker speech intelligibility.
Sci Rep
December 2024
Department of Communication Science and Disorders, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Multi-talker speech intelligibility requires successful separation of the target speech from background speech. Successful speech segregation relies on bottom-up neural coding fidelity of sensory information and top-down effortful listening. Here, we studied the interaction between temporal processing measured using Envelope Following Responses (EFRs) to amplitude modulated tones, and pupil-indexed listening effort, as it related to performance on the Quick Speech-in-Noise (QuickSIN) test in normal-hearing adults.
View Article and Find Full Text PDFNeural markers of error processing relate to task performance, but not to substance-related risks and problems and externalizing problems in adolescence and emerging adulthood.
Dev Cogn Neurosci
December 2024
PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway; Center for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Detecting errors and adapting behavior accordingly constitutes an integral aspect of cognition. Previous studies have linked neural correlates of error processing (e.g.
View Article and Find Full Text PDFSorting it Out: Adolescent Refugee's Perceptions of Food Upon Arrival to the US.
Public Health Nutr
December 2024
Department of Epidemiology, Emory University.
Objective: To explore the meanings that newly-arrived refugee adolescents residing in the Southeast U.S. attribute to foods.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!