AI Article Synopsis
- Desmoplasia is a sign that pancreatic cancer might be really serious, and this study looks at how heat affects collagen in tendon and tumor cells.
- Researchers found that using mild heat can hurt the structure of collagen in both tendon tissues and pancreatic tumors made in a lab.
- Mild heat treatment reduces the life of cancer cells, causing them to die more often, which could help in understanding how to treat pancreatic cancer better.
Article Abstract
Desmoplasia, an aberrant production of extracellular matrix (ECM), is considered as one predictive marker of malignancy of pancreatic cancer. In this paper, we study the effect of mild hyperthermia on fibrillary collagen architecture in murine Achilles tendons and in a pancreatic cancer model, in vitro, i.e. 3D hetero-type tumor spheroids, consisting of pancreatic cancer (Panc-1) cells and fibroblasts (WI-38), producing collagen fibers. We clearly demonstrate that i) mild hyperthermia (40 °C, 42 °C) damages the collagen architecture in murine Achilles tendons. ii) Mild extrinsic (hot air) and iron oxide nanoparticle based magnetic hyperthermia reduce the level of collagen fiber architecture in the generated hetero-type tumor spheroids. iii) Mild magnetic hyperthermia reduces cell vitality mainly through apoptotic and necrotic processes in the generated tumor spheroids. In conclusion, hetero-type 3D tumor spheroids are suitable for studying the effect of hyperthermia on collagen fibers, in vitro.
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| http://dx.doi.org/10.1016/j.nano.2020.102183 | DOI Listing |
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