To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Panton-Valentine leukocidin-positive isolates were 17%, and 6% of the isolates were methicillin-resistant Staphylococcus aureus. Multivariate analysis identified Panton-Valentine leukocidin presence (adjusted odds ratio, 12.6; P = 0.01) as the only factor independently associated with severe outcome, regardless of methicillin resistance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/INF.0000000000002640 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Macrophage Activation Syndrome in a Patient with Systemic Lupus Erythematous Triggered by Tuberculous Meningitis.
Eur J Case Rep Intern Med
December 2024
Internal Medicine, Dubai Health, Dubai, United Arab Emirates.
Background: Hemophagocytic lymphohistiocytosis (HLH), is characterized by systemic uncontrolled inflammation resulting from immune dysregulation secondary to various triggers, including genetics, infections, autoimmune diseases, and malignancies. Macrophage activation syndrome (MAS) is an immune dysregulation phenomenon, in which an underlying rheumatological disease is present. We report a rare, interesting case of a middle-aged female, with a systemic lupus erythematosus (SLE) flare complicated by macrophage activation syndrome (MAS), in which tuberculous meningitis (TBM) was the identified trigger.
View Article and Find Full Text PDFRespiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report.
Am J Hematol
December 2024
Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy.
Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season.
View Article and Find Full Text PDFThe Complicated Case of Staphylococcus aureus Bacteremia Associated With Delayed-Onset Prosthetic Joint Infection: A Case Report and Review of Management Strategies.
Cureus
August 2024
Internal Medicine, Insight Hospital and Medical Center, Chicago, USA.
(), an opportunistic Gram-positive bacterium, is notorious for causing a plethora of clinical diseases. While it does not typically infect healthy skin, infections are prevalent in both community-acquired and hospital-acquired settings. Rheumatoid arthritis (RA), a chronic autoimmune disease characterized by joint inflammation and progressive bone erosion, can be managed medically and, in moderate to severe cases, surgically through arthroplasty.
View Article and Find Full Text PDFClinical presentation and microbiological characteristics of community-acquired bacteraemia at a tertiary hospital in Costa Rica.
J Med Microbiol
September 2024
Faculty of Microbiology and Research Center for Tropical Diseases (CIET), Universidad de Costa Rica, San José, Costa Rica.
is a leading agent in community-acquired bacteraemia (CAB) and has been linked to elevated mortality rates and methicillin resistance in Costa Rica. To update and enhance previous data obtained in this country, we analysed the clinical manifestations of 54 CAB cases in a tertiary hospital and delineated the sequence types (STs), virulome, and resistome of the implicated isolates. Clinical information was retrieved from patient files.
View Article and Find Full Text PDFAntibiotic prescribing practices and antibiotic use quality indicators in Luang Prabang, Lao PDR: a point prevalence survey in a tertiary care hospital.
BMC Infect Dis
August 2024
Fondation Mérieux, Lyon, France.
Context: The increase and global dissemination of antibiotic resistance limit the use of antibiotics to prevent and treat infections. Implementing antibiotic stewardship programs guided by local data on prescription profiles is a useful strategy to reduce the burden of antibiotic resistance. The aim was to determine the prevalence of antibiotic use and guideline compliance at Luang Prabang provincial hospital, Lao PDR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!