AI Article Synopsis
- * Isoliquiritigenin demonstrated stronger neuroprotective and antioxidant effects compared to quercetin, a known natural antioxidant, by reducing harmful substances and improving protective enzyme activities.
- * The compound also reduced cell death by stabilizing mitochondrial function and altering gene expressions related to oxidative stress and apoptosis.
Article Abstract
Glycyrrhizae radix has been widely accepted as a functional food in Asia. Isoliquiritigenin is a characteristic bioactive chemical in this medicinal plant. In this work, the neuroprotective effect of isoliquiritigenin and the possible mechanisms were investigated. The results revealed that isoliquiritigenin exhibited better neuroprotective and antioxidant activities than quercetin, a commercial natural antioxidant. Isoliquiritigenin significantly inhibited the release of lactate dehydrogenase, and the generation of reactive oxygen species in HO-treated cells. The activities of superoxide dismutase, glutathione peroxidase and catalase were improved. The mRNA expression levels related to oxidative defense and cell apoptosis were reversed by isoliquiritigenin. Moreover, isoliquiritigenin might inhibit the cell apoptosis via ameliorating the loss of mitochondrial membrane potential and the change of nucleus morphology.
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| http://dx.doi.org/10.1016/j.freeradbiomed.2020.03.016 | DOI Listing |
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