Unlabelled: plays an important role in the development of dental caries in humans by synthesizing adhesive insoluble glucans from sucrose by mutansucrase activity. To explore the anti-cariogenic characteristics of rubusoside (Ru), a natural sweetener component in (Rosaceae), we investigated the inhibitory effect of Ru against the activity of mutansucrase and the growth of Ru (50 mM) showed 97% inhibitory activity against 0.1 U/mL mutansucrase of with 500 mM sucrose. It showed competitive inhibition with a value of 1.1 ± 0.2 mM and IC of 2.3 mM. Its inhibition activity was due to hydrophobic and hydrogen bonding interactions based on molecular docking analysis. Ru inhibited the growth of as a bacteriostatic agent, with MIC and MBC values of 6 mM and 8 mM, respectively. In addition, Ru showed synergistic anti-bacterial activity when it was combined with curcumin. Therefore, Ru is a natural anti-cariogenic agent with anti-mutansucrase activity and antimicrobial activity against .
Electronic Supplementary Material Esm: The online version of this article (doi: 10.1007/s12257-018-0408-0) contains supplementary material, which is available to authorized users.
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