AI Article Synopsis
- Acute stress significantly contributes to the onset of anxiety disorders, and zebrafish are commonly used to study the brain's response to stress and anxiety.
- The research focused on how acute restraint stress affects cell activation in the telencephalon of adult zebrafish, revealing reduced c-fos protein expression and lower GABA release following stress.
- The findings suggest that decreased GABA levels lead to less activation of GABAA receptors, resulting in heightened anxiety-like behavior, and indicate zebrafish may be useful for testing anxiolytic drugs targeting the GABAergic system.
Article Abstract
Acute stress is an important factor in the development of anxiety disorders. Zebrafish are an organism model widely used by studies that aim to describe the events in the brain that control stress-elicited anxiety. The goal of the current study was to evaluate the pattern of cell activation in the telencephalon of adult zebrafish and the role of the GABAergic system on the modulation of anxiety-like behavior evoked by acute restraint stress. Zebrafish that underwent acute restraint stress presented decreased expression of the c-fos protein in their telencephalon as well as a significant decrease in GABA release. The data also supports that decreased GABA levels in zebrafish brains have diminished the activation of GABAA receptors eliciting anxiety-like behavior. Taken together these findings have helped clarify a neurochemical pathway controlling anxiety-like behavior evoked by acute stress in zebrafish while also opening the possibility of new perspective opportunities to use zebrafish as an animal model to test anxyolitic drugs that target the GABAergic system.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099036 | PMC |
| http://dx.doi.org/10.1038/s41598-020-62077-w | DOI Listing |
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