AI Article Synopsis
- Advances in medical and surgical techniques have improved early survival rates after liver transplantation, with the study focusing on the impact of portocaval shunt (PCS) on mortality rates within the first 12 months.
- The study analyzed data from 231 liver transplant recipients, finding an 85.2% overall survival rate, with infections being the leading cause of death, followed by multiorgan failure.
- Key risk factors for mortality included surgical complications and renal replacement therapy, while PCS was associated with a significant 70% reduction in mortality risk, highlighting the need for further research to confirm these findings.
Article Abstract
Background: Advances in medical management and surgical technique have resulted in stepwise improvements in early post-transplant survival rates. Modifications in the surgical technique, such as the realization of the portocaval shunt (PCS), could influence survival rates. The aim of this study was to evaluate the mortality rate for 12 months after liver transplantation, analyzing the causes and risk factors related to its development and assessing the impact that PCS could have on them.
Methods: A total of 231 recipients were included in the retrospective, longitudinal, and nonrandomized study.
Results: The overall survival of the transplant was 85.2% (197 patients). The most frequent cause of death was infection (38.2%), followed by the multiorgan failure of multiple etiology (23.5%). Most of the risk factors related to mortality correspond to variables of the postoperative period. The results of the multivariate analysis identified the main risk factors for death: the presence of surgical complications and the need for renal replacement therapy. In contrast, the performance of PCS exerted a protective effect, reducing the probability of death by 70%.
Conclusions: Despite the good results obtained in several studies, there is still debate regarding the benefit of its realization. In our study, PCS was a factor associated with a reduction in mortality, with a markedly lower probability of adverse events. However, we agree with other authors on the need for larger and randomized studies to adequately determine the validity of such results.
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| http://dx.doi.org/10.1016/j.transproceed.2020.01.089 | DOI Listing |
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