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-geranylated flavonoids: their structural variety, biological activity and application prospects. | LitMetric
species, especially their flowers and fruits, are traditionally used in Chinese herbal medicines for the treatment of infectious diseases. -geranylated flavonoids were found to be the major special metabolites in flowers and fruits, and 76 -geranylated flavonoids had been isolated and characterized thus far. Structural variations in C-geranylated flavonoids are mainly due to the complicated structural modifications in their geranyl substituents. These natural compounds have attracted much attention because of their various biological activities, including antioxidation, anti-inflammation, cytotoxic activity and various enzymatic inhibitions, etc. Among them, diplacone, a major component, was considered to have promise for applications in medicine. This paper summarizes the information from current publications on -geranylated flavonoids, with a focus on their structural variety, key spectroscopic characteristics, biological activity with structure-activity relationships and application prospects. We hope that this paper will stimulate further investigations of species and this kind of natural product.
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