AI Article Synopsis
- Studies reviewed focus on how animal viral proteins affect cells by using individuals with transgenes from these viruses.
- The findings indicate that virus-host specificity is largely dictated by viral proteins that help the virus enter cells, while proteins that interact with host cells show less specificity.
- This model can be utilized to identify potential intracellular targets for the less-host-specific viral proteins.
Article Abstract
Studies in which individuals carrying transgenes of animal viruses were used to analyze the action of animal viral proteins on the cell are reviewed. The data presented suggest that host specificity of viruses is determined by their proteins responsible for the penetration of the virus into the cell, while viral proteins responsible for interactions with the host cell are much less host-specific. Due to this, the model of with its developed system of searching for genetic interactions can be used to find intracellular targets for the action of viral proteins of the second group.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088594 | PMC |
| http://dx.doi.org/10.1134/S1022795411040090 | DOI Listing |
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