Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases.

Adenosine is involved in a range of physiological and pathological effects through membrane-bound receptors linked to G proteins. There are four subtypes of adenosine receptors, described as AAR, AAR, AAR, and AAR, which are the center of cAMP signal pathway-based drug development. Several types of agonists, partial agonists or antagonists, and allosteric substances have been synthesized from these receptors as new therapeutic drug candidates. Research efforts surrounding AAR and AAR are perhaps the most enticing because of their concentration and affinity; however, as a consequence of distressing conditions, both AAR and AAR levels might accumulate. This review focuses on the biological features of each adenosine receptor as the basis of ligand production and describes clinical studies of adenosine receptor-associated pharmaceuticals in human diseases.