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| http://dx.doi.org/10.1177/2050640620910847 | DOI Listing |
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Characterising the metabolic functionality of the preterm neonatal gut microbiome prior to the onset of necrotising enterocolitis: a pilot study.
BMC Microbiol
December 2024
Translational and Clinical Research Institute, Newcastle University, 3Rd Floor Leech Building, Newcastle Upon TyneNewcastle, NE2 4HH, UK.
Background: Necrotising enterocolitis (NEC) is a devastating bowel disease that primarily occurs in infants born prematurely and is associated with abnormal gut microbiome development. While gut microbiome compositions associated with NEC have been well studied, there is a lack of experimental work investigating microbiota functions and their associations with disease onset. The aim of this pilot study was to characterise the metabolic functionality of the preterm gut microbiome prior to the onset of NEC compared with healthy controls.
View Article and Find Full Text PDFThe Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis.
J Transl Med
November 2024
Department of Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing, Jiangsu Province, 210029, China.
Glucocorticoids (GCs) are key inducers of osteonecrosis, yet not all patients treated with GCs develop glucocorticoid-associated osteonecrosis (GAON). The factors mediating this relationship are unclear. Studies have shown that gut microbiota and their metabolites influence bone metabolism, but their role in GAON is unclear.
View Article and Find Full Text PDFKnowledge and perceptions of South African blood donors towards biobanking and stool donation.
S Afr J Infect Dis
October 2024
Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Article Synopsis
- A study was conducted in South Africa to assess the feasibility of establishing a stool donor bank in collaboration with WCBS and UCT, focusing on the willingness of blood donors to donate stool samples for microbiome research.
- The survey, conducted with 209 blood donors, revealed that compensation and the perceived societal benefits significantly influenced the willingness to donate, while age also played a minor role.
- The findings highlight important factors for potential donors and mark the first investigation into the perspectives of participants for a stool microbiome biobank in South Africa, which is crucial for fecal microbiota transplantation (FMT).
Tuning the Electronic Properties of Azophosphines as Ligands and Their Application in Base-Free Transfer Hydrogenation Catalysis.
Organometallics
October 2024
School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
The design and tuning of new ligands is crucial for unlocking new reactivity at transition metal centers. Azophosphines have recently emerged as a new class of 1,3-P,N ligands in ruthenium piano-stool complexes. This work shows that the azophosphine synthesis can tolerate -aryl substituents with strongly electron-donating and electron-withdrawing -R groups and that the nature of this R group can affect the spectroscopic and structural properties of the azophosphines, as measured by NMR spectroscopy, UV-vis spectroscopy, single-crystal X-ray diffraction, and DFT studies.
View Article and Find Full Text PDFChanges in intestinal permeability and gut microbiota following diet-induced weight loss in patients with metabolic dysfunction-associated steatohepatitis and liver fibrosis.
Gut Microbes
September 2024
Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, St Mary's Hospital, Imperial College London, London, UK.
Article Synopsis
- * The study found that a decrease in serum zonulin levels (a marker of intestinal permeability) was correlated with both weight loss and a reduction in liver fat, indicating improved metabolic health.
- * While initial changes in gut microbiota and short-chain fatty acids (SCFAs) occurred at 12 weeks, these effects did not persist at 24 weeks, suggesting that longer-term benefits in MASH may not be linked to sustained changes in the gut microbiome.
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