AI Article Synopsis
- Osteoarthritis (OA) is a common degenerative disease affecting joint cartilage, and researchers are investigating human amniotic mesenchymal stem cells (hAMSCs) as a therapy for cartilage repair.
- A new treatment involving a combination of hAMSCs and hyaluronic acid (HA) was tested in rats and showed significant cartilage regeneration after 56 days, comparable to healthy cartilage.
- The study suggests that HA enhances hAMSCs' effectiveness by improving their abilities to differentiate, multiply, and aid in regeneration, indicating a promising direction for OA treatment through straightforward injection therapy.
Article Abstract
Osteoarthritis (OA) is one of the most common refractory degenerative articular cartilage diseases. Human amniotic mesenchymal cells (hAMSCs) have emerged as a promising stem cell source for cartilage repair, and hyaluronic acid (HA) has proven to be a versatile regulator for stem cell transplantation. Herein, an effective and straightforward intra-articular injection therapy using a cocktail of hAMSCs and HA was developed to treat knee OA in a rat model. The injured cartilage was remarkably regenerated, yielding results comparable to normal cartilage levels after 56 days of treatment. Both hAMSCs and HA were indispensable organic components in this therapy, in which HA could synergistically enhance the effects of hAMSCs on cartilage repair. The regenerative mechanism was attributed to the fact that the addition of HA comprehensively enhances the activities of hAMSCs, including chondrogenic differentiation, proliferation, colonization, and regenerative modulation. This cocktail paves a new avenue for injection therapy to treat OA, holding the potential to realize rapid clinical translation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068044 | PMC |
| http://dx.doi.org/10.3389/fbioe.2020.00087 | DOI Listing |
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