ign of Sustainable Chemoenzymatic Organic Transformations in for the Synthesis of 1,2-Disubstituted Aromatic Olefins.

The self-assembly of styrene-type olefins into the corresponding stilbenes was conveniently performed in the () mixture 1/2 under air and in the absence of hazardous organic co-solvents using a one-pot chemo-biocatalytic route. Here, an enzymatic decarboxylation of -hydroxycinnamic acids sequentially followed by a ruthenium-catalyzed metathesis of olefins has been investigated in . Moreover, and to extend the design of chemoenzymatic processes in , we also coupled the aforementioned enzymatic decarboxylation reaction to now concomitant Pd-catalyzed Heck-type C-C coupling to produce biaryl derivatives under environmentally friendly reaction conditions.