This manuscript details the modifications made to the HPLC assay method described in the USP monograph for Acetazolamide Compounded Oral Suspension.•The method was modified to allow the quantification of acetazolamide in two new suspension vehicles: Oral Mix and Oral Mix SF;•It was validated for linearity, accuracy, precision and specificity;•It was demonstrated stability-indicating and suitable for use in a stability study using these vehicles.
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http://dx.doi.org/10.1016/j.mex.2020.100844 | DOI Listing |
J Pharm Biomed Anal
January 2025
Pharmaceutical Products Department, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil. Electronic address:
Glaucoma, a leading cause of irreversible blindness, affects about 70 million people globally. Its treatment focuses on reducing intraocular pressure. Acetazolamide, a potent anti-glaucoma drug, is currently used only systemically due to low solubility and permeation, which cause severe side effects.
View Article and Find Full Text PDFMikrochim Acta
May 2024
Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, 06560, Turkey.
The first electrochemical sensor application in the literature is described for the sensitive and selective determination of the selective Janus kinase (JAK)-1 inhibitor abrocitinib (ABR). ABR is approved by the U.S.
View Article and Find Full Text PDFPLoS One
March 2023
Department of Radiology, Gifu University, Gifu, Japan.
Biology (Basel)
September 2022
Unit of Forensic Toxicology, Section of Legal Medicine, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, Via Tronto 10/a, 60126 Ancona, AN, Italy.
Carbonic anhydrase inhibitors (CAIs) are prescription drugs also used in doping to dilute urine samples and tamper with urinalyses. Dorzolamide, brinzolamide, and acetazolamide are prohibited by the World Anti-Doping Agency. Detecting CAIs and their metabolites in biological samples is crucial to documenting misuse in doping.
View Article and Find Full Text PDFJ Pharm Biomed Anal
September 2022
Laboratoire Génie des Procedés & Environnement, Faculté des Sciences et Techniques, Hassan II University of Casablanca, B.P. 146, Mohammedia, Morocco. Electronic address:
In this work, a competitive assay based on molecularly imprinted polymer (MIP) is developed for the rapid screening of acetazolamide (ACZ) using a colorimetric method coupled with smartphone-based detection. Because of it is an analog of ACZ and its ability to be transformed into a colored product, sulfamethoxazole (SMX) was used as a competitor to indirectly determine ACZ from the inhibition degree of SMX onto the MIP. It was found firstly that ACZ-SMX competition was not possible without using support.
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