AI Article Synopsis
- The malfunction of the protein HtrA2/Omi is linked to Parkinson's disease, but its specific role in the disease mechanism was previously unclear.
- Research demonstrated that HtrA2/Omi can selectively degrade toxic oligomeric forms of alpha-synuclein without affecting normal monomeric forms, protecting against neurodegeneration.
- Experiments in mutant mice and fruit flies showed that HtrA2/Omi's action not only alleviated Parkinsonism symptoms but also promoted brain health and longevity, indicating its potential as a therapeutic target for Parkinson's disease.
Article Abstract
Although the malfunction of HtrA2/Omi leads to Parkinson's disease (PD), the underlying mechanism has remained unknown. Here, we showed that HtrA2/Omi specifically removed oligomeric α-Syn but not monomeric α-Syn to protect oligomeric α-Syn-induced neurodegeneration. Experiments using mnd2 mice indicated that HtrA2/Omi degraded oligomeric α-Syn specifically without affecting monomers. Transgenic Drosophila melanogaster experiments of the co-expression α-Syn and HtrA2/Omi and expression of genes individually also confirmed that pan-neuronal expression of HtrA2/Omi completely rescued Parkinsonism in the α-Syn-induced PD Drosophila model by specifically removing oligomeric α-Syn. HtrA2/Omi maintained the health and integrity of the brain and extended the life span of transgenic flies. Because HtrA2/Omi specifically degraded oligomeric α-Syn, co-expression of HtrA2/Omi and α-Syn in Drosophila eye maintained a healthy retina, while the expression of α-Syn induced retinal degeneration. This work showed that the bacterial function of HtrA to degrade toxic misfolded proteins is evolutionarily conserved in mammalian brains as HtrA2/Omi.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093540 | PMC |
| http://dx.doi.org/10.1038/s41598-020-62309-z | DOI Listing |
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