Goodyschle A (), a new butenolide, was isolated from the whole grass of , an orchidaceous edible medicinal plant. The structure of the new compound was elucidated by 1 D and 2 D NMR experiments in addition to HRESIMS analyses. Compound was evaluated for its bioactivities including cytotoxic activity against human gastric cancer (SGC-7901) and human hepatocellular carcinoma (HepG2) cell lines, inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and DPPH radical scavenging activity. As a result, compound showed potent BChE inhibitory activity (IC value = 6.88 ± 1.63 μM), moderate DPPH radical scavenging activity (IC value = 16.25 ± 0.21 μM), and slight AChE inhibitory and cytotoxic activities. These findings suggest that compound is worthy for further investigations in terms of its selective BChE inhibitory activity.
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| http://dx.doi.org/10.1080/14786419.2020.1744142 | DOI Listing |
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