AI Article Synopsis
- The rise of antibiotic-resistant bacteria has led to the exploration of alternative treatments, particularly targeting lipase, an enzyme found in many bacteria.
- This study examines five boron dipyrrolylmethene (BODIPY) derivatives for their ability to target lipase and exhibit antibacterial properties, with one compound, BDP-2, showing effectiveness against E. coli.
- The modified version, BDP2-Br@mPEG nanoparticles, demonstrated low toxicity to cancer cells and effective bacterial membrane disruption when exposed to green LED light, indicating its potential as a new antibacterial treatment.
Article Abstract
The increasing number of resistant bacterial strains has raised efforts in developing alternative treatment strategies. Lipase is highly expressed in most bacteria and lipase targeting dyes will be non-sacrificed materials for a sustainable method against microorganism. The combination of chemotherapy and antimicrobial photodynamic inactivation (aPDI) method will be an effective method due to enhanced antibacterial activity. Here we reported the spectroscopic features of five boron dipyrrolylmethene (BODIPY) derivatives with different functional groups for lipase affinity and antibacterial activity. Lipase affinity tests and antibacterial assays were conducted by spectroscopic methods. Adamantane-conjugated BODIPY (BDP-2) was found to be the active compound against E. coli. Next, BDP-2 was brominated, and then assembled with PEG resulting biocompatible BDP2-Br@mPEG nanoparticles. The MTT assay indicated that BDP2-Br@mPEG was less toxicity on BGC-823 cancer cells without irradiation. The BDP2-Br@mPEG can inhibit the proliferation of E. coli and damage the membrane of bacterial cell under green LED light irradiation. The results proved BDP2-Br@mPEG can be a very promising green LED light driven antibacterial material.
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| http://dx.doi.org/10.1016/j.saa.2020.118252 | DOI Listing |
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