Prior to Darwin's masterworks, a university professor of medicine's purview generally included the professorship of botany and direction of the botanical gardens. Yet from the landmark 1876 Johns Hopkins model and especially after the 1910 Flexner Report, botany was limited at certain medical schools to (exaggerating somewhat) "decorating their lobbies!" Darwinian-era scientific paradigms spread from continental Europe through promulgators such as Huxley and Osler, transforming laboratory research, disease aetiology, biochemical therapeutics, and clinical "bedside" teaching. Unintended consequences at universities with medical schools might include altered loyalties and resources among competing disciplines. At the University of Toronto, botany vis-à-vis medicine was gradually treated as passé or secondary to zoology for modern, scientific platforms. This pattern was not universal; botany strongholds at universities such as Harvard continued to flourish. Where a negative perspective took hold with evolutionary impacts, botanists' careers became limited and the impetus for maintaining botanic research and teaching facilities such as a university botanical gardens was impaired.
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http://dx.doi.org/10.3138/cbmh.413-012020 | DOI Listing |
Int J Immunogenet
January 2025
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India.
The association between heterozygous C4 deficiency and systemic lupus erythematosus (SLE) is unclear. There is a lack of data in South Asian Indians on any possible association of C4A and C4B null alleles with lupus. We aimed to study the prevalence of C4A and C4B null alleles in a cohort of SLE patients with persistently low C4 levels compared to healthy controls (HC).
View Article and Find Full Text PDFNat Commun
January 2025
British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamined in childhood. We analyzed cheek swabs from 4626 typically developing children 2-months to 20-years-old.
View Article and Find Full Text PDFBMC Emerg Med
January 2025
Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Background: Globally, healthcare institutions have seen a marked rise in workplace violence (WPV), especially since the Covid-19 pandemic began, affecting primarily acute care and emergency departments (EDs). At the University Health Network (UHN) in Toronto, Canada, WPV incidents in EDs jumped 169% from 0.43 to 1.
View Article and Find Full Text PDFIntroduction: The Lung Clearance Index (LCI) is an established research test, but its role in clinical decision-making is not well defined. This study estimated the proportion of treatment decisions that are changed or supported by the added information provided by LCI.
Methods: A mixed methods prospective observational study was conducted in North America.
J Prev Alzheimers Dis
January 2025
Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada; Schulich Interfaculty Program in Public Health, Western University, London, ON, Canada; Centre for Medical Evidence, Decision Integrity and Clinical Impact, London, ON, Canada; WHO Collaborating Centre for Knowledge Translation and Health Technology Assessment in Health Equity, Ottawa, Canada; Department of Health Sciences, University of York, York, UK; Centre for Addiction and Mental Health, Institute for Mental Health Policy Research, Toronto, Ontario, Canada; Department of Psychology, Macquarie University, Sydney, Australia. Electronic address:
Aim: Neurological disorders account for the largest proportion of disability-adjusted life years globally, with dementia being the third leading cause. Hypertension has been identified as a priority, targetable risk factor for dementia. This study aimed to systematically review economic studies that examine the impact of hypertension prevention and control on the costs and outcomes of dementia.
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