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Plasmacytoid dendritic cell sensing of African swine fever virus-infected macrophages results in STING-dependent robust interferon-α production.
J Immunol
January 2025
Institute of Virology and Immunology, Mittelhäusern, Switzerland.
While several African swine fever virus (ASFV)-encoded proteins potently interfere with the cGAS-STING (cyclic GMP-AMP synthetase-stimulator of interferon genes) pathway at different levels to suppress interferon (IFN) type I production in infected macrophages, systemic IFN-α is induced during the early stages of AFSV infection in pigs. The present study elucidates a mechanism by which such responses can be triggered, at least in vitro. We demonstrate that infection of monocyte-derived macrophages (MDMs) by ASFV genotype 2 strains is highly efficient but immunologically silent with respect to IFN type I, IFN-stimulated gene induction, and tumor necrosis factor production.
View Article and Find Full Text PDFPVR exposure influences the activation, adhesion, and protein expression of human CD8+ T cells, including the CD96-mediated transfer of PVR.
J Immunol
January 2025
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, United States.
Poliovirus receptor (PVR) ligands have gained attention as immunotherapy targets, yet their regulation remains unclear. Here, we examine the impact of PVR exposure on primary human CD8+ T cells. We used flow cytometry and Western blot analysis to quantify expression of PVR and its ligands in naïve and effector T cells and used adhesion assays and enzyme-linked immunosorbent assay (ELISA) to assess the impact of PVR on T cell adhesion and cytokine production.
View Article and Find Full Text PDFSustainable visions: unsupervised machine learning insights on global development goals.
PLoS One
March 2025
Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Coyoacán, Ciudad de México, México.
The 2030 Agenda for Sustainable Development of the United Nations outlines 17 goals for countries of the world to address global challenges in their development. However, the progress of countries towards these goal has been slower than expected and, consequently, there is a need to investigate the reasons behind this fact. In this study, we have used a novel data-driven methodology to analyze time-series data for over 20 years (2000-2022) from 107 countries using unsupervised machine learning (ML) techniques.
View Article and Find Full Text PDFTemporal Dynamics of Microbial Community Composition and Antimicrobial Resistance in a Mass Gathering Setting Using Culturomics and Metagenomic Approaches.
J Epidemiol Glob Health
March 2025
Microbiological Type Culture Collection and Gene Bank (MTCC), CSIR Institute of Microbial Technology, Chandigarh, 160036, India.
Introduction: Antimicrobial resistance (AMR) is one of the major global concerns in the current scenario. Mass-gathering events in fast-developing and densely populated areas may contribute to antibiotic resistance. Despite meticulous planning and infrastructure development, the effect of mass gatherings on microbial ecosystems and antibiotic resistance must be investigated.
View Article and Find Full Text PDFDiscordance between patient and physician global assessments of psoriatic arthritis activity: an observational study in 13 Arab countries.
Rheumatol Int
March 2025
Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie Et de Santé Publique, Paris, France.
Discordance between physicians and patients in assessing psoriatic arthritis (PsA) activity is common and might impact treatment adherence and decision-making. Cultural and belief systems may influence this discordance. This study aimed to assess the extent of patient-physician discordance in PsA in Arab countries and its association with demographic and disease characteristics.
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