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| http://dx.doi.org/10.1093/jncics/pkz097 | DOI Listing |
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Long-term impact of Diabetes Prevention Program interventions on walking endurance.
Front Public Health
January 2025
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Objectives: Type 2 diabetes (T2D) and prediabetes are associated with poor walking endurance, a marker of physical function. We aimed to examine the long-term effects of metformin or intensive lifestyle intervention in adults at high risk of T2D on their 6-min walk test (6MWT) performance.
Methods: Participants were randomized in the 3-year Diabetes Prevention Program (DPP) to one of the three groups: lifestyle intervention, metformin, or placebo, and were subsequently followed in the DPP Outcomes Study.
Article Synopsis
- The study focuses on understanding how different types of exercise and metformin impact vascular health in diabetic rats, particularly looking at oxidative stress and inflammation.
- The research involved inducing diabetes in rats and subjecting them to various treatments, revealing that all treatments improved crucial biochemical markers related to diabetes.
- Notably, combining exercise with metformin showed greater benefits, especially with interval training, suggesting a dual approach could enhance therapy for diabetes-related cardiovascular issues.
Differential impact of lifestyle factors on 2-hour glucose values in individuals with type 2 diabetes: potential for more personalized interventions.
BMJ Open Diabetes Res Care
December 2024
Endocrinology, Leiden Universitair Medisch Centrum, Leiden, Netherlands.
Introduction: Lifestyle determinants of 2-hour glucose concentration in people with type 2 diabetes and interindividual differences need to be identified.
Research Design And Methods: 38 participants with type 2 diabetes, treated with lifestyle advice and/or metformin, tracked their physical activity, sleep and dietary intake, while continuously monitoring interstitial glucose concentrations for 11 periods of four consecutive days each. A linear mixed-effects model was used to quantify the effect of sleep, stress, current glucose, carbohydrate intake and exercise on glucose levels 2 hours later.
Neonatal amino acid metabolism in gestational diabetes mellitus mothers treated with different treatment strategies.
J Diabetes Metab Disord
June 2025
Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, 16 Dingxiang Road, Changzhou, 213000 China.
Objectives: The changes in amino acid (AA) levels have been observed in pregnant women with gestational diabetes mellitus (GDM). However, it remains unclear whether the AA levels in offspring of GDM mothers are affected by GDM. This study aimed to investigate the changes in AA metabolism in offspring of pregnant women with GDM undergoing different glycemic control treatment regimens.
View Article and Find Full Text PDFEffect of metformin on exercise capacity in treatment naïve type 2 diabetes patients.
Drug Metab Pers Ther
December 2024
Department of Clinical Pharmacology, 29988 JIPMER , Puducherry, India.
Objectives: Exercise capacity is decreased in diabetes mellitus due to impaired insulin sensitivity, endothelial dysfunction and mitochondrial dysfunction. The aim of the study was to evaluate the effect of metformin on exercise capacity in treatment naïve patients with type 2 diabetes mellitus.
Methods: Newly diagnosed type 2 diabetes mellitus patients were tested for baseline insulin resistance and exercise capacity, before starting on metformin.
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