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YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. | LitMetric

AI Article Synopsis

  • - HNSCC is a common and aggressive cancer type, with oral SCC (OSCC) being a significant subtype that severely impacts patient survival.
  • - Research shows that hyperactivation of YAP1 promotes rapid tumor development in mice, leading to tongue cancer in as little as two weeks.
  • - Targeting YAP1 could serve as a potential treatment for OSCC and HNSCC, with new mouse models aiding in the evaluation of this therapeutic approach.

Article Abstract

Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common group of cancers in the world, and patients have a poor prognosis. Here, we present data indicating that YAP1 may be a strong driver of the onset and progression of oral SCC (OSCC), a major subtype of HNSCC. Mice with tongue-specific deletion of and thus endogenous YAP1 hyperactivation underwent surprisingly rapid and highly reproducible tumorigenesis, developing tongue carcinoma in situ within 2 weeks and invasive SCC within 4 weeks. In humans, precancerous tongue dysplasia displays YAP1 activation correlating with reduced patient survival. Combinations of molecules mutated in OSCC may increase and sustain YAP1 activation to the point of oncogenicity. Strikingly, siRNA or pharmacological inhibition of YAP1 blocks murine OSCC onset in vitro and in vivo. Our work justifies targeting YAP1 as therapy for OSCC and perhaps HNSCC, and our mouse model represents a powerful tool for evaluating these agents.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080500PMC
http://dx.doi.org/10.1126/sciadv.aay3324DOI Listing

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