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http://dx.doi.org/10.1007/s13193-019-00982-xDOI Listing

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Clinical and Imaging Outcomes of Doxycycline Exchange Sclerotherapy for Lymphatic Malformations.

J Vasc Interv Radiol

December 2024

The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Purpose: To evaluate serial doxycycline exchanges (SDEs) to treat lymphatic malformations (LMs).

Materials And Methods: Retrospective chart review of patients undergoing LM sclerotherapy with SDEs at our tertiary care academic institution from April 2003 through March 2023. Primary outcome measure was change in symptoms between pre- and post-treatment clinical notes.

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Article Synopsis
  • * After surgery, the cyst came back aggressively, prompting further intervention.
  • * The recurrence was effectively treated using percutaneous doxycycline sclerotherapy, which is considered a low-risk option for such cases.
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Purpose: To propose a standardized method of subjectively and objectively evaluating outcomes of sclerotherapy in treating low flow vascular malformations.

Materials And Methods: Sixty-six patients with low flow vascular malformations (venous, lymphatic, or combined) were treated with percutaneous sclerotherapy using bleomycin, doxycycline, or sodium tetradecyl sulphate. Each lesion required between 2-5 sessions of sclerotherapy with 8-week intervals in between.

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Aim: Lymphatic malformations (LMs) and Veno-lymphatic malformations (VLMs) are congenital slow flow vascular malformations. Intralesional sclerotherapy is a good alternate option for treatment of LMs and VLMs. Our aim was to evaluate the outcome of doxycycline sclerotherapy for lymphatic and veno-lymphatic malformation in children in our institute.

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  • * This report discusses three pediatric cases where mandibular ABCs were effectively treated with image-guided doxycycline sclerotherapy, highlighting varying presentations and previous treatment experiences among the patients.
  • * All patients showed resolution of symptoms and demonstrated successful bone healing without any functional or aesthetic complications, indicating that doxycycline sclerotherapy is a safe and effective treatment option for both new and recurring mandibular ABCs.
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