Objectives: The aims of the study were to evaluate clinicopathologic features, management, and outcomes in vulval melanoma and to review the literature.
Materials And Methods: Data were collected retrospectively on patients with vulval melanoma from 2001 to 2017 in 5 gynecological oncology cancer centers (Bristol, Taunton, Truro, Plymouth, and Cheltenham). SPSS software was used for univariate and multivariate statistical analysis. Disease-specific median survival was calculated using Kaplan-Meier curves.
Results: Forty-four patients with vulval melanoma were included, with a median age of 71 years. Forty-three of 44 had wide local excision with full inguinal lymphadenectomy if abnormal lymph nodes. Seven patients had sentinel lymph nodes. However, 2 patients with negative sentinel lymph nodes had distant recurrences within 16 months.On univariate analysis, presence of ulceration (p = .012), perineural invasion (p = .03), and area of lesion (p = .016) were associated with risk of recurrence but only presence of microsatellites (p = .01) was associated with risk of death.There were 31 deaths (70%): 29 (94%) of 31 from melanoma and 28 (64%) of 44 recurrences: 17 local (10 groin, 7 vulval) and 9 distant. Overall median survival was 32.5 months (95% CI, 17.8-46.5 months) and median recurrence-free survival 12.6 months (95% CI, 7.7-17.4 months).
Conclusions: This retrospective multicenter study highlights the high recurrence rate and poor prognosis of vulval melanoma. Lymph node surgery did not make any difference to recurrence-free survival or overall survival. The presence of microsatellites was associated with a statistically increased risk of death.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/LGT.0000000000000521 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Treatment Outcomes of Vulvar Cancer: Our Experience From a Tertiary Care Center in Eastern India.
Cureus
November 2024
Surgical Oncology, All India Institute of Medical Sciences, Patna, Patna, IND.
Article Synopsis
- Vulvar carcinoma, primarily squamous cell carcinoma, is a rare form of cancer occurring in the external female genitalia, necessitating a multidisciplinary treatment approach often involving surgery and adjuvant therapy based on stage and other factors.
- A retrospective study conducted in India over eight years included 21 patients with vulvar cancer, analyzing disease stages, treatment methods, and outcomes, revealing a five-year survival rate of about 71%.
- The study highlighted the importance of individualized treatment plans and the need for strict protocols and regular follow-ups, especially in low-resource settings, to improve patient outcomes in this rare disease.
Clinicopathologic features and surgical management in vulvovaginal melanoma - A retrospective single-center study.
J Plast Reconstr Aesthet Surg
October 2024
Department of Plastic Surgery, Helsinki University, Helsinki University Hospital, Helsinki, Finland.
Article Synopsis
- Vulvovaginal melanoma is a rare and aggressive form of cancer with low survival rates, reviewed in a study at Helsinki University Hospital over two decades.
- The majority of cases occurred in the vulva (86%), with surgery being the primary treatment method (86% of patients), but recurrences were common, particularly in distant sites.
- Key findings indicated that while wide local excision may be a viable treatment option, nodal status significantly impacts overall survival, highlighting the need for more research on lymph node evaluation in these patients.
Basosquamous Carcinoma Arising from the Vulva: A Case Report.
Case Rep Oncol
November 2024
Faculty of Medicine of Tunis, University of Tunis Manar, Tunis, Tunisia.
Article Synopsis
- * A case study of a 59-year-old woman showed a painful, slow-growing vulvar lesion diagnosed as BSC, confirmed by biopsy and treated with partial radical vulvectomy and sentinel lymph node biopsy, both showing no evidence of metastasis.
- * This case highlights the importance of recognizing squamous differentiation in BSC for ensuring complete surgical excision, as it has a higher risk of recurrence and metastasis compared to basal cell carcinoma,
A Rare Case of Primary Vulval Amelanotic Melanoma Involving the Urethra.
Prague Med Rep
August 2024
Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Foggia, Italy.
A 60-year-old woman came to the Emergency Department complaining of a vaginal formation. The urologist suspected a urethral caruncle: the patient was discharged with vaginal oestrogen cream to relieve symptoms and a follow-up was suggested. After two months the patient returned to the Emergency Department since the mass was increasing in volume and complaining of dysuria and haematuria.
View Article and Find Full Text PDFBackground: Lichen sclerosus (LS) is a chronic, inflammatory skin disease with a predilection for the genitalia. Although, the association between squamous cell cancer and genital LS is well established, a link with genital melanoma has not been thoroughly explored. However, we have recently published a case series of penile melanoma where 9/11 (82%) of patients seen over a 10 year period with penile melanoma were retrospectively found to have histological and/or clinical evidence of genital LS on review.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!