We argue that enhanced Traffic Control Bundling (eTCB) can interrupt the community-hospital-community transmission cycle, thereby limiting COVID-19's impact. Enhanced TCB is an expansion of the traditional TCB that proved highly effective during Taiwan's 2003 SARS outbreak. TCB's success derived from ensuring that Health Care Workers (HCWs) and patients were protected from fomite, contact and droplet transmission within hospitals. Although TCB proved successful during SARS, achieving a similar level of success with the COVID-19 outbreak requires adapting TCB to the unique manifestations of this new disease. These manifestations include asymptomatic infection, a hyper-affinity to ACE2 receptors resulting in high transmissibility, false negatives, and an incubation period of up to 22 days. Enhanced TCB incorporates the necessary adaptations. In particular, eTCB includes expanding the TCB transition zone to incorporate a new sector - the quarantine ward. This ward houses patients exhibiting atypical manifestations or awaiting definitive diagnosis. A second adaptation involves enhancing the checkpoint hand disinfection and gowning up with Personal Protective Equipment deployed in traditional TCB. Under eTCB, checkpoint hand disinfection and donning of face masks are now required of all visitors who seek to enter hospitals. These enhancements ensure that transmissions by droplets, fomites and contact are disrupted both within hospitals and between hospitals and the broader community. Evidencing eTCB effectiveness is Taiwan's success to date in containing and controlling the community-hospital-community transmission cycle.
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http://dx.doi.org/10.1016/j.jmii.2020.03.011 | DOI Listing |
J Physiol
January 2025
Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.
Here we characterize seven Cx30.3 gene variants (R22H, S26Y, P61R, C86S, E99K, T130M and M190L) clinically associated with the rare skin disorder erythrokeratodermia variabilis et progressiva (EKVP) in tissue-relevant and differentiation-competent rat epidermal keratinocytes (REKs). We found that all variants, when expressed alone or together with wildtype (WT) Cx30.
View Article and Find Full Text PDFHeliyon
July 2024
School of Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom.
Road traffic accidents pose a significant global health concern, with an alarming 1.19 million fatalities reported in 2021. Traditionally, strategies to address this challenge have relied on expert input and subjective evaluations.
View Article and Find Full Text PDFEnviron Technol
January 2025
Department of Sanitary and Environmental Engineering, Federal University of Santa Catarina, Florianópolis, Brazil.
Precise estimates of vehicular emissions at fine spatial scales are essential for effective emission reduction strategies. Achieving high-resolution vehicular emission inventories necessitates detailed data on traffic flow, driving patterns, and vehicle speeds for each road network segment. However, in developing countries, the lack of comprehensive traffic data, limited infrastructure, and insufficient monitoring systems constrains the development of high-resolution inventories.
View Article and Find Full Text PDFData Brief
February 2025
North Carolina Agricultural and Technical State University, 1601 E Market St, Greensboro, NC 27411, United States.
Contemporary research in 3D object detection for autonomous driving primarily focuses on identifying standard entities like vehicles and pedestrians. However, the need for large, precisely labelled datasets limits the detection of specialized and less common objects, such as Emergency Medical Service (EMS) and law enforcement vehicles. To address this, we leveraged the Car Learning to Act (CARLA) simulator to generate and fairly distribute rare EMS vehicles, automatically labelling these objects in 3D point cloud data.
View Article and Find Full Text PDFAfr J Emerg Med
December 2024
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Background: In Nigeria, trauma care faces challenges due to high injury and death rates from road traffic accidents and violence. Improvements are underway, but gaps in service availability, training, and coordination persist, necessitating evidence-based interventions.
Purpose: To evaluate trauma care practices in Nigeria, focusing on practitioners' perceptions of training, resources, and care quality to inform policy and practice enhancements.
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