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Association between Cerebral Oxygen Saturation with Outcome in Cardiac Surgery: Brain as an Index Organ. | LitMetric

Association between Cerebral Oxygen Saturation with Outcome in Cardiac Surgery: Brain as an Index Organ.

J Clin Med

Department of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.

Published: March 2020

AI Article Synopsis

  • - The study investigated how baseline and intraoperative decreases in regional cerebral oxygen saturation (rSO) affect health outcomes in cardiac surgery patients who underwent interventions to correct these decreases.
  • - Researchers analyzed data from 356 patients and found that a significant drop in rSO (measured as AUT50) was linked to higher risks of negative outcomes, alongside factors like age and kidney health.
  • - The findings emphasize the critical role of monitoring cerebral oxygen levels during surgery, as significant rSO decreases could indicate adverse consequences for patients even after corrective measures are taken.

Article Abstract

While both baseline regional cerebral oxygen saturation (rSO) and intraoperative rSO decreases have prognostic importance in cardiac surgery, evidence is limited in patients who received interventions to correct rSO decreases. The primary aim was to examine the association between rSO values (both baseline rSO and intraoperative decrease in rSO) with the composite of morbidity endpoints. We retrospectively analyzed 356 cardiac surgical patients having continuously recorded data of intraoperative rSO values. Per institutional guidelines, patients received interventions to restore the rSO value to ≥80% of the baseline value. Analyzed rSO variables included baseline value, and area under the threshold below an absolute value of 50% (AUT50). Their association with outcome was analyzed with multivariable logistic regression. AUT50 (odds ratio, 1.05; 95% confidence interval; 1.01-1.08; = 0.015) was shown to be an independent risk factor (along with age, chronic kidney disease, and cardiopulmonary bypass time) of adverse outcomes. In cardiac surgical patients who received interventions to correct decreases in rSO, increased severity of intraoperative decrease in rSO as reflected by AUT below an absolute value of 50% was associated with a composite of adverse outcomes, implicating the importance of cerebral oximetry to monitor the brain as an index organ.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141352PMC
http://dx.doi.org/10.3390/jcm9030840DOI Listing

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