Nasopharyngeal carcinoma (NPC) is leading form of cancer occurring in a few well-defined regions, including southern China. NPC possess a unique and intricate etiology that remains to be elucidated. Herein, we determine expression patterns of and and identify their roles in NPC. Gene-expression profiles of NPC in the Gene Expression Omnibus (GEO) were analyzed. Cell viability, invasion, apoptosis, cell cycle entry and mitochondrial membrane potential (MMP) were evaluated in the presence of or in the absence of . In all, 187 upregulated genes and 683 downregulated genes were obtained by analyzing GSE13597. , the downregulated gene, and , the upregulated one, were further confirmed by studies. Overexpression of was shown to inhibit NPC cell viability and invasion. Knockdown of was demonstrated to reduce cell cycle entry and MMP but induce apoptosis in NPC cells. Taken together, the key finding obtained from the study supports and as two promising therapeutic candidates for NPC. Molecular mechanisms that control or disturbance require further investigation and clarification.
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