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Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from . | LitMetric

Chromatographic purification of the DCM sub-extract of led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (), together with five known compounds. Among the compounds isolated, zeylenone () showed moderate antitubercular activity against HRv with MIC value of 51.2 μM and antiproliferative or cytotoxic activity against human myeloid leukaemia (K-562) and HeLa cells with IC values of 2.3 and 18.3 μM, respectively.

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http://dx.doi.org/10.1080/14786419.2020.1741579DOI Listing

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