AI Article Synopsis
- Antithymocyte globulin (ATG) is used in hematopoietic stem cell transplantation (HSCT) to reduce the risk of graft rejection and graft-versus-host disease.
- Weight-based dosing of ATG aims to improve its effectiveness, but many patients still show significant differences in how the body clears the drug.
- More research is needed to understand how ATG works in various HSCT scenarios and among patients with different health conditions.
Article Abstract
Antithymocyte globulin (ATG) is a widely accepted part of the conditioning regimen applied in the setting of hematopoietic stem cell transplantation (HSCT) to prevent graft rejection and graft-versus-host disease. Although weight-based dosing of ATG has been introduced to optimize ATG dosing, substantial variance in clearance of active ATG, the actual lymphocyte binding component, remains a challenge. Therefore, further research regarding ATG pharmacokinetics and pharmacodynamics in different HSCT settings and in patients with different types of underlying diseases is required.
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| http://dx.doi.org/10.1016/j.hemonc.2019.12.003 | DOI Listing |
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