Objective: To compare follicular flushing with a double-lumen needle with direct aspiration on the number of oocytes collected in a poor responder population in IVF.
Study Design: We conducted a randomized controlled prospective single-center study between March 2011 and June 2016 at the ART center in the Medico-Surgical and Obstetric Center in Schiltigheim, France. Patients undergoing IVF who had ≤ 4 follicles ≥ 14 mm on the day of HCG administration were recruited and then randomized to one of two groups : simple aspiration group (= NO FLUSH) with a single-lumen 17-gauge needle or follicular flushing group (= FLUSH) which underwent oocyte puncture with aspiration and follicular flushing with a double-lumen 17-gauge needle. The primary end-point was the number of oocytes collected. Secondary assessment criteria were the fertilization rate, the number of transferable embryos, the number of clinical pregnancies and their outcome.
Results: 252 patients were included: 127 in the Flush group and 125 in the No flush The number of oocytes retrieved per patient was significantly lower in the FLUSH group: 2.41 than in the NO FLUSH group: 3.42 (p < 0.001). The number of transferable embryos, fertilization rate (68.8 % in the FLUSH group versus 75 % p = 0.682), or pregnancy rate weren't different but (15 versus 13). However the number of failed punctures was significantly higher in the FLUSH group (11 % versus 3.2 % p = 0.016) and the duration of oocyte retrieval was significantly longer in the FLUSH group where the median time was 10 min whereas it was only 7 min in the NO FLUSH group, p < 0.001 CONCLUSION: Follicular flushing in poor responders is not beneficial and could be detrimental with an increasing procedure time and less oocytes retrieved.
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http://dx.doi.org/10.1016/j.ejogrb.2020.03.003 | DOI Listing |
Clin Cancer Res
January 2025
Vall d'Hebron Institute of Oncology, Barcelona, Spain.
Introduction: Elacestrant has shown significantly prolonged progression-free survival compared to standard-of-care endocrine therapy in estrogen receptor-positive (ER-positive), HER2-negative metastatic breast cancer (BC), while potential benefit in early-stage disease requires further exploration. The SOLTI-ELIPSE window-of-opportunity trial investigated the biological changes induced by a short course of preoperative elacestrant in postmenopausal women with early BC.
Methods: Eligible patients with untreated T1c (≥1.
Int J Soc Determinants Health Health Serv
January 2025
Unit of Occupational Medicine, Karolinska Institute, Sweden.
Precarious employment (PE) is a major determinant of population health and contributor to health and social inequities. The purpose of this article is to synthesize and critically appraise available evidence on labor market initiatives addressing PE identified through a systematic review. Of the 21 initiatives reviewed, grouped into four categories-labor market policies, legislation, and reforms; union strategies; apprenticeships and other youth programs; social protection programs-10 showed consistently positive outcomes and 11 a combination of negative, mixed, or inconclusive outcomes.
View Article and Find Full Text PDFWillows (genus ) are increasingly used in operational-scale ecosystem reclamation; however, different opinions exist regarding the optimal cutting size for planting under field conditions. We compared the survival of field-planted willow cuttings sourced from upland and lowland areas with varying diameters and lengths across two growing seasons. Cuttings were grouped into 15 size classes with different diameters (0.
View Article and Find Full Text PDFInt J Dent
January 2025
Department of Conservative Dentistry and Endodontics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Due to the presence of ion reservoir, saliva may facilitate enamel remineralization and neutralize pH of acidic beverage leads to prevent enamel demineralization. Saliva substitute/artificial saliva has been developed in subsequent years and may differ in physical properties, function, or pH level from 5.0 to 7.
View Article and Find Full Text PDFTaiwan J Obstet Gynecol
January 2025
Reproductive Medicine Center, Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan. Electronic address:
Objective: To evaluate the effectiveness of oocyte retrieval using a single-lumen aspiration needle compared to a double-lumen aspiration needle in IVF (in vitro fertilization) patients.
Materials And Methods: This retrospective cohort study included all IVF cycles between 1st January, 2020 and 31st December, 2022 in Changhua Christian Hospital, Taiwan. Pairwise comparisons were conducted through propensity score matching analysis at a 1:3 ratio according to patients' age, anti-Müllerian hormone levels, and body weight.
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