AI Article Synopsis
- Stressful early life events, like maternal separation, disrupt feeding behavior and the serotonergic system in adult animals.
- The study focused on middle-aged female rats separated from their mothers for two weeks, showing altered eating patterns tied to their serotonin levels.
- Results indicated that maternal separation led to decreased food intake and altered meal behaviors, with a link to increased serotonin receptor activity in the brain, suggesting long-term impacts of early stress on behavior.
Article Abstract
Stressful events occurring during early life have been related to behavioral and neurochemical disturbances. Maternal separation during the first two weeks of life is a traumatic event that strongly affects the feeding behavior and serotonergic system of the progeny in adulthood. As this system modulates the feeding behavior, the present study aimed at investigating the effects of maternal separation-induced stress on both the feeding behavior and serotonergic system of the middle-aged female rats by manipulating this system using fluoxetine, a selective serotonin transporter inhibitor. Lactating Wistar rats were separated from their litters from postnatal day 2 (PND 2) to PND 14 for 3 h in the dark phase of the circadian cycle. The maternally separated (MS) and control (C) groups were distinguished from each other based on the incidence or absence of maternal separation (early life stress). All the analyses were done on the female offspring from one-year of age. Maternal separation anticipated the satiety point in these females. This anticipation was linked to lower food intake, meal duration and meal size. These results mirrored the effects of fluoxetine in the control animals. Furthermore, maternal separation was associated with 5ht1b serotonin receptor hyperexpression in the hypothalamus. These findings demonstrate that maternal separation has long-lasting effects on the eating behavior and serotonergic system and that this system could be responsible for mediating these behavioral outcomes.
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| http://dx.doi.org/10.1016/j.pbb.2020.172908 | DOI Listing |
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