AI Article Synopsis
- Most human cancers exhibit aneuploidy due to chromosomal instability (CIN), but the exact role of CIN in cancer development remains unclear despite animal studies.
- In a conditional mouse model, researchers found that moderate levels of CIN lead to an increased formation of adenomas in the intestines, particularly in the distal colon, in mice predisposed to intestinal cancer.
- Interestingly, while high levels of CIN significantly boost adenoma formation in the distal colon, they do not impact the small intestine, suggesting that CIN has variable effects across different tissues.
Article Abstract
Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still unclear. Using a conditional mouse model for diverse degrees of CIN, we find that a particular range is sufficient to drive very early onset spontaneous adenoma formation in the intestine. In mice predisposed to intestinal cancer (Apc), moderate CIN causes a remarkable increase in adenoma burden in the entire intestinal tract and especially in the distal colon, which resembles human disease. Strikingly, a higher level of CIN promotes adenoma formation in the distal colon even more than moderate CIN does, but has no effect in the small intestine. Our results thus show that CIN can be potently oncogenic, but that certain levels of CIN can have contrasting effects in distinct tissues.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083897 | PMC |
| http://dx.doi.org/10.1038/s41467-020-15279-9 | DOI Listing |
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