Blood damage (hemolysis) can occur during clinical procedures, e.g. dialysis, due to human error or faulty equipment, and it can cause significant harm to the patient or even death. We propose a simple technique to monitor changes in hemolysis levels continuously and in real time. As red blood cells rupture, the overall conductivity of the blood increases. Here, we demonstrate that small changes in porcine blood hemolysis can be detected through a simple resistance measurement.
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http://dx.doi.org/10.1038/s41598-020-62041-8 | DOI Listing |
Crit Rev Anal Chem
January 2025
Department of Chemistry, Government Degree College, Doda, India.
This review article highlights the importance of novel charge transfer (CT) sensing approach for the detection of ions which are crucial from environmental and biological point of view. The importance, principles of charge transfer, ion sensing, its different types, and its basic process will all be covered here. The strategy has been reported with enormous sensitivity and fast signaling response owing to the fact that strong electronic connection communication exists between donor (D) and acceptor (A) part.
View Article and Find Full Text PDFChembiochem
January 2025
Shiv Nadar University, CHEMISTRY, NH 91, TEHSIL DADRI, GAUSTAM BUDHA NAGAR, 201314, GREATER NOIDA, INDIA.
Reactive oxygen species (ROS) play crucial roles in both cell signaling and defense mechanisms. Hypochlorous acid (HOCl), a strong oxidant, aids the immune response by damaging pathogens. In this study, we developed two pyridinium-based fluorophores PSSM and PSSE for selective hypochlorite detection.
View Article and Find Full Text PDFJ Clin Med
January 2025
Anesthesiology, Critical Care and Pain Medicine Division, Department of Medicine and Surgery, University of Parma, Viale Gramsci 14, 43126 Parma, Italy.
Sepsis is one of the leading causes of mortality in hospital settings, and early diagnosis is a crucial challenge to improve clinical outcomes. Artificial intelligence (AI) is emerging as a valuable resource to address this challenge, with numerous investigations exploring its application to predict and diagnose sepsis early, as well as personalizing its treatment. Machine learning (ML) models are able to use clinical data collected from hospital Electronic Health Records or continuous monitoring to predict patients at risk of sepsis hours before the onset of symptoms.
View Article and Find Full Text PDFJ Clin Med
January 2025
Departamento de Genética, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), Mexico City 14269, Mexico.
: Antiseizure drugs (ASDs) are the primary therapy for epilepsy, and the choice varies according to seizure type. Epilepsy patients experience chronic mitochondrial oxidative stress and increased levels of pro-inflammatory mediators, recognizable hallmarks of biological aging; however, few studies have explored aging markers in epilepsy. Herein, we addressed for the first time the impact of ASDs on molecular aging by measuring the telomere length (TL) and mtDNA copy number (mtDNA-CN).
View Article and Find Full Text PDFJ Clin Med
December 2024
Prisma Health, University of South Carolina School of Medicine, Columbia, SC 29601, USA.
: The main aim of this study is to analyze the outcomes of NSTEMI admissions and test the relevance of TIMI as a risk score in a real-world setting. We also examine any potential social or health care disparities involved with outcomes of NSTEMI admissions. This study also investigates factors associated with mortality in NSTEMI admissions and its correlation with heart catheterization during admission.
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