Insulin-stimulated trafficking of GLUT4 requires the myosin motor Myo1C and signaling adaptor 14-3-3β. Originally, it was thought that 14-3-3β promotes GLUT4 transport by binding the Myo1C lever arm and activating the Myo1C motor. New work by Ji and Ostap using assays reveals that 14-3-3β binding actually inhibits Myo1C motility, prompting reconsideration of the functional relationship between 14-3-3β and Myo1C and the regulatory potential of atypical light chains.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086042 | PMC |
| http://dx.doi.org/10.1074/jbc.H120.013153 | DOI Listing |
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