Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146445 | PMC |
| http://dx.doi.org/10.3390/molecules25061389 | DOI Listing |
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