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Immunological differences between monophasic and biphasic synovial sarcoma with implications for immunotherapy.
Cancer Immunol Immunother
December 2024
Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Synovial sarcoma is an aggressive soft-tissue cancer that shows limited responses to current immunotherapeutic approaches using immune checkpoint blockade or adoptive cell therapy. To improve immunotherapy for this cancer, understanding how the immune cells in the tumor microenvironment associate with histological subtype, disease progression and current therapies is vital. To evaluate the immune infiltrate in synovial sarcoma in relation to histological subtype, disease progression and in response to cytotoxic treatment, we performed immunodetection of T cells, CD68 myeloid cells, endothelial cells and keratin on a series of 41 synovial sarcoma patients at various stages of disease.
View Article and Find Full Text PDFSS18-SSX drives TYK2 expression to activate STAT3/Bcl2 axis, facilitating apoptosis evasion and advancing synovial sarcoma progression.
Cell Biol Toxicol
December 2024
The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Synovial sarcoma (SS) is a rare soft tissue sarcoma characterized by high-grade malignancy and poor prognosis. Preliminary research indicates that apoptosis evasion is a key factor in SS progression, primarily attributed to the overexpression of anti-apoptotic genes. However, the mechanisms underlying this phenomenon are still not fully understood.
View Article and Find Full Text PDFAnakinra in relapsing polychondritis: a case report and review of the literature.
Immunotherapy
December 2024
Department of Clinical Immunology and Allergy, Flinders Medical Centre, Bedford Park, South Australia.
Relapsing polychondritis is rare and affects non-synovial fibrocartilage. Currently, there is a paucity of treatment algorithms, especially for those with refractory disease. A middle-aged man presented with polychondritis affecting the nose, ears, joints, and larynx.
View Article and Find Full Text PDFSynovial sarcoma of the larynx, a rare and unusual entity. Case report.
Int J Surg Case Rep
December 2024
Pathology Department, National Medical Center "20 de Noviembre", Mexico City, MX. Mexico.
Introduction And Importance: Synovial sarcoma (SS) is a high-grade malignancy, accounting for 2.5-3.5 % of all primary H&N sarcomas and 0.
View Article and Find Full Text PDFLipoma arborescens in a 22-year-old male: A case report.
Medicine (Baltimore)
December 2024
Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong, China.
Rationale: Lipoma arborescens (LA) is a rare, benign proliferative disorder of the synovial lining that typically affects middle-aged individuals, predominantly in the knee joint. However, its occurrence in younger patients is unusual and may pose unique diagnostic and therapeutic challenges. This case report aims to highlight the clinical, imaging, and therapeutic aspects of LA in a young adult, thereby expanding the understanding of its presentation in this age group.
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