Gallium-68 (Ga) is an important radionuclide due to its successful use in the clinic. Currently, Ga is produced and supplied by using germanium-68/Gallium-68 (Ge/Ga) generator systems in the preclinical and clinical environments. Until recently, the supply of Ge/Ga generators, specifically the good manufacturing practices (GMP) grade, had a long lead time (up to 18 months). This led researchers to investigate the cyclotron production of Ga by using solid and liquid targets. This report summarizes an overview of the chemistry, coordination chemistry, and radiochemistry of Ga and the current status of manufacturing and supply of Ga radionuclide.
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| http://dx.doi.org/10.1089/cbr.2019.3301 | DOI Listing |
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