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Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography - Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy.
Indian J Urol
January 2025
Department of Urology, Apollo Hospital, Chennai, Tamil Nadu, India.
Introduction: Gallium-68 prostate-specific membrane antigen positron emission tomography (Ga-PSMA PET) is being increasingly used in patients with prostate cancer (PCa) for the staging and detection of lymph node (LN) metastases, despite a lack of prospective, validated evidence. We aimed to investigate the relationship between the PSMA PET findings (maximum standardized uptake [SUV] value) and the final histopathology results (Gleason Grade [GG], and LN positivity) in patients undergoing radical prostatectomy.
Methods: This is a single centre, prospective, observational study of 63 consecutive eligible patients treated at a tertiary care centre in India.
Can lesion volume and prostate-specific antigen density play a role in detecting clinically significant prostate cancer in Prostate Imaging Reporting and Data System-3 lesions on multiparametric magnetic resonance imaging?
Indian J Urol
January 2025
Uro-Oncology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Introduction: Recently, the Prostate Imaging Reporting and Data System - 3 lesions (PI-RADS 3) have been sub classified into "3a" - lesions with a volume of <0.5 mL and "3b" - lesions exceeding 0.5 mL, whereas the prostate-specific antigen density (PSAD) is an established adjunct tool for predicting clinically significant prostate cancer (csPCa).
View Article and Find Full Text PDFAge-disproportionate atrophy in Alzheimer's disease and Parkinson's disease spectra.
Alzheimers Dement (Amst)
January 2025
Introduction: Brain age gap (BAG), defined as the difference between MRI-predicted 'brain age' and chronological age, can capture information underlying various neurological disorders. We investigated the pathophysiological significance of the BAG across neurodegenerative disorders.
Methods: We developed a brain age estimator using structural MRIs of healthy-aged individuals from one cohort study.
Association of arterial structure and function with incident cardiovascular diseases and cognitive decline.
Alzheimers Dement (Amst)
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Introduction: We examined the associations of carotid intima-media thickness (CIMT), arterial stiffness index (ASI), and pulse pressure (PP) with cerebrovascular disease, cognitive function and decline, and incident cardiovascular diseases (CVD) and dementia in the UK Biobank cohort.
Methods: The study consisted of 42,711 participants (mean age 64.2 years) with brain magnetic resonance imaging (MRI), vascular assessments, and cognitive testing.
The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function.
Front Immunol
January 2025
Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Introduction: Chimeric antigen receptor (CAR) expressing T-cells have shown great promise for the future of cancer immunotherapy with the recent clinical successes achieved in treating different hematologic cancers. Despite these early successes, several challenges remain in the field that require to be solved for the therapy to be more efficacious. One such challenge is the lack of long-term persistence of CD28 based CAR T-cells in patients.
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