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Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight. | LitMetric

AI Article Synopsis

  • Retinol-binding protein 2 (RBP2) is important for absorbing dietary retinoids in the small intestine, and its absence in mice leads to increased body weight, impaired glucose metabolism, and higher liver triglycerides as they age.
  • These issues are also seen in young mice on a high-fat diet, indicating a broader metabolic impact.
  • RBP2 acts as a binding protein for monoacylglycerols (MAGs), engaging with the endocannabinoid 2-AG, which suggests that RBP2 plays a crucial role in regulating energy balance and signaling beyond its function in retinoid absorption.

Article Abstract

Expressed in the small intestine, retinol-binding protein 2 (RBP2) facilitates dietary retinoid absorption. -deficient ( ) mice fed a chow diet exhibit by 6-7 months-of-age higher body weights, impaired glucose metabolism, and greater hepatic triglyceride levels compared to controls. These phenotypes are also observed when young mice are fed a high fat diet. Retinoids do not account for the phenotypes. Rather, RBP2 is a previously unidentified monoacylglycerol (MAG)-binding protein, interacting with the endocannabinoid 2-arachidonoylglycerol (2-AG) and other MAGs with affinities comparable to retinol. X-ray crystallographic studies show that MAGs bind in the retinol binding pocket. When challenged with an oil gavage, mice show elevated mucosal levels of 2-MAGs. This is accompanied by significantly elevated blood levels of the gut hormone GIP (glucose-dependent insulinotropic polypeptide). Thus, RBP2, in addition to facilitating dietary retinoid absorption, modulates MAG metabolism and likely signaling, playing a heretofore unknown role in systemic energy balance.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065888PMC
http://dx.doi.org/10.1126/sciadv.aay8937DOI Listing

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