Objective: Complex depressed scars can cause tissue adhesion, resulting in serious joint dysfunction. In recent years, autologous adipose and adipose-derived stem cells have been widely used to treat depressed scars, but there are still limitations in these treatment that should be resolved. This study aimed to investigate the therapeutic effects of adipose tissues collected with modified technique on the depressed scars in animals.
Methods: The adipose tissues were collected with a forward technique, and tissue viability in vitro and the survival of transplanted tissues in in nude mice were further assessed. Furthermore, the therapeutic effects of adipose tissues collected with new technique and traditional technique on the depressed scars were explored in an animal model of bleomycin induced scar formation.
Results: The adipose tissues collected with the new technique had a higher glucose transport (P<0.01); after transplantation into the nude mice, the amount of residual tissues and the survival rate in the modified group were higher than in the traditional group (P<0.05); electron microscopy showed the intercellular space was covered with reticular structure, in which there was a large amount of microvessel structure in the adipose tissue of the modified group; immunohistochemistry showed that the microvessel density (MVD) in the modified group increased significantly (P<0.01). At 28 d after transplantation into the scar animals, the dermal collagen fibers became thicker and showed regular arrangement, the myofibroblasts became regenerative and inflammation was improved as compared to blank control group. In the untreated scar group, the collagen fibers were loose and irregular, and a large amount of inflammatory cells was observed. In addition, the dermal expression of α-SMA and TGF-β in the transplantation group reduced significantly as compared to scar group (P<0.05).
Conclusion: The autologous adipose tissues collected with the new technique possess higher activity ad contain more. In scar animals, transplantation of these adipose tissues may improve the scar structure and inhibit the scar formation which may be related to the suppressed expression of α-SMA and TGF-β.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061831 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Background: Acne is an inflammatory skin disease afflicting the majority of the world's population at some point in their lifetime, and is seen to be chronic in about 50% of cases. Acne leads to significant social withdrawal, depression, and disfiguring scars in many cases. Available treatments are characterized by high rates of relapse, dangerous side effects, and social stigma, which often leads to poor patient compliance and treatment failure.
View Article and Find Full Text PDFPediatric Hidradenitis Suppurativa: An Overview.
Skin Therapy Lett
January 2025
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.
Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory skin disease that significantly impacts the quality of life of patients.[1] HS is more common in adults and adolescents, although true incidence rates may be underestimated due to a lack of earlier recognition of HS in children.[2] Pediatric HS is a challenging clinical entity to diagnose and manage.
View Article and Find Full Text PDFAn Exploratory Study of PN HPT for Treating Postsurgical Atrophic and Depressed Scars.
J Cosmet Dermatol
January 2025
Clinical Pharmacology Consultant in Aesthetic Medicine, Milan, Italy.
Background: Postsurgical atrophic scars tend to respond poorly to treatments, especially non-energy-based ones. Hydrophilic PN HPT (Polynucleotides High Purification Technology) injected intradermally is a non-energy-based option with an immediate volume-enhancing effect that indirectly improves the fibroblast synthesis of collagen and extracellular matrix. The PN HPT ingredient has the further benefit of a dermal "priming" effect that enhances the efficacy of other scar treatments.
View Article and Find Full Text PDFThe Correlation Between Progressive Hemifacial Atrophy and Mandibular Hyaluronic Acid Injection: A Case Report.
J Craniofac Surg
January 2025
Department of Cosmetic Injection Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Hyaluronic acid filler treatment is increasingly prevalent in the realm of plastic surgery, serving to correct a range of facial changes resulting from aging. Nevertheless, with its expanded application, an uptick in complications has been observed. This article reported a 30-year-old female patient who received chin hyaluronic acid filler treatment 5 years ago started experiencing atrophy and progressive deterioration at the injection site a year ago.
View Article and Find Full Text PDFAdults With Head and Neck Burns Experience Worse Long-Term Outcomes and Require More Reconstructive Surgeries: A Burn Model System Study.
Ann Plast Surg
February 2025
Division of Plastic and Reconstructive Surgery, University of Southern California, Los Angeles, CA.
Background: Adults living with head and neck burn injuries experience psychosocial consequences due to scarring as well as functional disabilities. However, the impact of head and neck burns on long-term self-reported psychosocial outcomes, return to work, and need for reconstructive surgery has not been well described. This study investigates the unique longitudinal problems in psychosocial and functional recovery faced by adults with head and neck burn injuries.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!